{"id":2565,"date":"2020-11-15T13:18:03","date_gmt":"2020-11-15T13:18:03","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2565"},"modified":"2020-11-15T13:18:03","modified_gmt":"2020-11-15T13:18:03","slug":"anti-human-cd19-antibody-clone-hib19-mouse-monoclonal-igg1-antibody-against-human-chimpanzee-cd19","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd19-antibody-clone-hib19-mouse-monoclonal-igg1-antibody-against-human-chimpanzee-cd19\/","title":{"rendered":"Anti-Human CD19 Antibody, Clone HIB19 Mouse monoclonal IgG1 antibody against human, chimpanzee CD19"},"content":{"rendered":"

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Overview<\/h3>\n
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The HIB19 antibody reacts with CD19, an ~95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells. Expression is down-regulated but persists in terminally differentiated plasma cells. CD19 is also found on follicular dendritic cells. By associating with CD21 and CD81, CD19 functions as a co-receptor for the B cell receptor and is involved in B cell activation and differentiation. Activation of CD19 is accompanied by phosphorylation of the cytoplasmic domain, which promotes binding to kinases and the induction of intracellular signaling cascades. Mutations in CD19 can result in severe immunodeficiency syndromes.<\/p>\n

This antibody clone has been verified for purity assessments of cells isolated with EasySep\u2122 kits, including EasySep\u2122 Human CD19 Positive Selection Kit , EasySep\u2122 Human Whole Blood CD19 Positive Selection Kit , EasySep\u2122 HLA Whole Blood B Cell Positive Selection Kit ; partial blocking may be observed, as well as EasySep\u2122 HLA B Cell Enrichment: Complete Processing Kit for Whole Blood and EasySep\u2122 HLA Total Lymphocyte Enrichment: Complete Processing Kit for Whole Blood .<\/p><\/div>\n

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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD19<\/div>\n<\/div>\n
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Alternative Names: B4<\/div>\n<\/div>\n
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Reactive Species: Chimpanzee; Human<\/div>\n<\/div>\n
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Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; PerCP-Cyanine5.5; Unconjugated<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: B Cells<\/div>\n<\/div>\n
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Application: Cell Isolation; Flow Cytometry; CyTOF; Functional Assay; Immunohistochemistry<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: HIB19<\/div>\n<\/div>\n
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Gene ID: 930<\/div>\n<\/div>\n
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Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The HIB19 antibody reacts with CD19, an ~95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells. Expression is down-regulated but persists in terminally differentiated plasma cells. CD19 is also found on follicular dendritic cells. By associating with CD21 and CD81, CD19 functions as a co-receptor for the B cell receptor and is involved in B cell activation and differentiation. Activation of CD19 is accompanied by phosphorylation of the cytoplasmic domain, which promotes binding to kinases and the induction of intracellular signaling cascades. Mutations in CD19 can result in severe immunodeficiency syndromes. This antibody clone has been verified for purity assessments of cells isolated with EasySep\u2122 kits, including EasySep\u2122 Human CD19 Positive Selection Kit , EasySep\u2122 Human Whole Blood CD19 Positive Selection Kit , EasySep\u2122 HLA Whole Blood B Cell Positive Selection Kit ; partial blocking may be observed, as well as EasySep\u2122 HLA B Cell Enrichment: Complete Processing Kit for Whole Blood and EasySep\u2122 HLA Total Lymphocyte Enrichment: Complete Processing Kit for Whole Blood . Subtype: Primary Antibodies Target Antigen: CD19 Alternative Names: B4 Reactive Species: Chimpanzee; Human Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; PerCP-Cyanine5.5; Unconjugated Host Species: Mouse Cell Type: B Cells Application: Cell Isolation; Flow Cytometry; CyTOF; Functional Assay; Immunohistochemistry Area of Interest: Immunology Clone: HIB19 Gene ID: 930 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2564,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2565","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2564"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2565"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2565"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2565"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}