{"id":2571,"date":"2020-11-15T13:30:42","date_gmt":"2020-11-15T13:30:42","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2571"},"modified":"2020-11-15T13:30:42","modified_gmt":"2020-11-15T13:30:42","slug":"anti-mouse-ifn-gamma-antibody-clone-xmg1-2-rat-monoclonal-igg1-antibody-against-mouse-ifn-gamma","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-ifn-gamma-antibody-clone-xmg1-2-rat-monoclonal-igg1-antibody-against-mouse-ifn-gamma\/","title":{"rendered":"Anti-Mouse IFN-gamma Antibody, Clone XMG1.2 Rat monoclonal IgG1 antibody against mouse IFN-gamma"},"content":{"rendered":"

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Overview<\/h3>\n
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The XMG1.2 antibody reacts with mouse interferon-gamma (IFN-\u03b3), a glycosylated type II interferon comprising a homodimer of ~20 kDa subunits in its active form. IFN-\u03b3 is produced primarily by activated T lymphocytes and natural killer (NK) cells in response to antigens, including alloantigens, mitogens, and enterotoxins. IFN-\u03b3 binds with high affinity to the \u03b1 subunit of the IFN-\u03b3 receptor, resulting in the ligand-induced assembly of a tetrameric \u03b12\u03b22 receptor complex capable of mediating the cellular response to the cytokine through activation of the JAK-STAT pathway. The IFN-\u03b3 receptor is expressed on the surface of all nucleated cells. IFN-\u03b3 has important functions in a wide range of biological processes, including macrophage activation, mediating the immune response to viruses and bacteria, and modulating cellular proliferation and apoptosis. The XMG1.2 antibody is suitable for detection of intracellular IFN-\u03b3 by methods such as flow cytometry, when paired with an appropriate secondary antibody. The XMG1.2 antibody is also widely used in various assays to neutralize the functional activity of IFN-\u03b3.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: IFN\u03b3<\/div>\n<\/div>\n
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Alternative Names: IFN-\u03b3, Immune interferon, Interferon-gamma, Macrophage-activating factor (MAF), T cell interferon, Type II interferon<\/div>\n<\/div>\n
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Reactive Species: Mouse<\/div>\n<\/div>\n
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Conjugation: APC; Biotin; FITC; PE<\/div>\n<\/div>\n
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Host Species: Rat<\/div>\n<\/div>\n
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Cell Type: Dendritic Cells; Macrophages; NK Cells; T Cells<\/div>\n<\/div>\n
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Application: ELISA; ELISpot; Flow Cytometry<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: XMG1.2<\/div>\n<\/div>\n
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Gene ID: 15978<\/div>\n<\/div>\n
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Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The XMG1.2 antibody reacts with mouse interferon-gamma (IFN-\u03b3), a glycosylated type II interferon comprising a homodimer of ~20 kDa subunits in its active form. IFN-\u03b3 is produced primarily by activated T lymphocytes and natural killer (NK) cells in response to antigens, including alloantigens, mitogens, and enterotoxins. IFN-\u03b3 binds with high affinity to the \u03b1 subunit of the IFN-\u03b3 receptor, resulting in the ligand-induced assembly of a tetrameric \u03b12\u03b22 receptor complex capable of mediating the cellular response to the cytokine through activation of the JAK-STAT pathway. The IFN-\u03b3 receptor is expressed on the surface of all nucleated cells. IFN-\u03b3 has important functions in a wide range of biological processes, including macrophage activation, mediating the immune response to viruses and bacteria, and modulating cellular proliferation and apoptosis. The XMG1.2 antibody is suitable for detection of intracellular IFN-\u03b3 by methods such as flow cytometry, when paired with an appropriate secondary antibody. The XMG1.2 antibody is also widely used in various assays to neutralize the functional activity of IFN-\u03b3. Subtype: Primary Antibodies Target Antigen: IFN\u03b3 Alternative Names: IFN-\u03b3, Immune interferon, Interferon-gamma, Macrophage-activating factor (MAF), T cell interferon, Type II interferon Reactive Species: Mouse Conjugation: APC; Biotin; FITC; PE Host Species: Rat Cell Type: Dendritic Cells; Macrophages; NK Cells; T Cells Application: ELISA; ELISpot; Flow Cytometry Area of Interest: Immunology Clone: XMG1.2 Gene ID: 15978 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2575,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2571","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2571","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2575"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2571"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2571"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2571"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2571"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}