{"id":2576,"date":"2020-11-15T13:35:45","date_gmt":"2020-11-15T13:35:45","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2576"},"modified":"2020-11-15T13:35:45","modified_gmt":"2020-11-15T13:35:45","slug":"anti-human-cd3-antibody-clone-okt3-mouse-monoclonal-igg2a-antibody-against-human-cd3","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd3-antibody-clone-okt3-mouse-monoclonal-igg2a-antibody-against-human-cd3\/","title":{"rendered":"Anti-Human CD3 Antibody, Clone OKT3 Mouse monoclonal IgG2a antibody against human CD3"},"content":{"rendered":"

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Overview<\/h3>\n
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The OKT3 antibody reacts with an extracellular conformational epitope on the ~20 kDa CD3\u03b5 subunit of the human T cell receptor (TCR)\/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NKT cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. CD3 is a dimer assembled from combinations of CD3\u03b3, \u03b4, \u03b5, \u03b7, and \u03b6 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily. CD3 associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating T cell activation and the expression of the TCR on the cell surface. Mutations in CD3 have been associated with disorders of the immune system, including severe combined immunodeficiency (SCID). The OKT3 antibody recognizes an epitope that is expressed when the CD3\u03b5 subunit associates with either CD3\u03b3 or CD3\u03b4, and binding of the antibody can induce T cell activation. Because of its immunosuppressive properties in vivo, the OKT3 antibody has proven useful in treating allograft rejection. Clone OKT3 is widely used for phenotyping human T cells, and it has been observed to block the binding of anti-CD3 antibody clones SK7 and UCHT1.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD3<\/div>\n<\/div>\n
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Alternative Names: CD3 epsilon, CD3\u03b5, Leu-4, T3<\/div>\n<\/div>\n
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Reactive Species: Human<\/div>\n<\/div>\n
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Conjugation: APC; FITC; Unconjugated<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: T Cells<\/div>\n<\/div>\n
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Application: Flow Cytometry; Functional Assay; Immunohistochemistry; Western Blotting<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: OKT3<\/div>\n<\/div>\n
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Gene ID: 916<\/div>\n<\/div>\n
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Isotype:\u00a0\u00a0\u00a0IgG2a, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The OKT3 antibody reacts with an extracellular conformational epitope on the ~20 kDa CD3\u03b5 subunit of the human T cell receptor (TCR)\/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NKT cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. CD3 is a dimer assembled from combinations of CD3\u03b3, \u03b4, \u03b5, \u03b7, and \u03b6 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily. CD3 associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating T cell activation and the expression of the TCR on the cell surface. Mutations in CD3 have been associated with disorders of the immune system, including severe combined immunodeficiency (SCID). The OKT3 antibody recognizes an epitope that is expressed when the CD3\u03b5 subunit associates with either CD3\u03b3 or CD3\u03b4, and binding of the antibody can induce T cell activation. Because of its immunosuppressive properties in vivo, the OKT3 antibody has proven useful in treating allograft rejection. Clone OKT3 is widely used for phenotyping human T cells, and it has been observed to block the binding of anti-CD3 antibody clones SK7 and UCHT1. Subtype: Primary Antibodies Target Antigen: CD3 Alternative Names: CD3 epsilon, CD3\u03b5, Leu-4, T3 Reactive Species: Human Conjugation: APC; FITC; Unconjugated Host Species: Mouse Cell Type: T Cells Application: Flow Cytometry; Functional Assay; Immunohistochemistry; Western Blotting Area of Interest: Immunology Clone: OKT3 Gene ID: 916 Isotype:\u00a0\u00a0\u00a0IgG2a, kappa<\/p>\n","protected":false},"featured_media":2579,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2576","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2579"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2576"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2576"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2576"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}