{"id":2582,"date":"2020-11-15T13:47:35","date_gmt":"2020-11-15T13:47:35","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2582"},"modified":"2020-11-15T13:47:35","modified_gmt":"2020-11-15T13:47:35","slug":"anti-human-hla-dr-antibody-clone-l243-mouse-monoclonal-igg2a-antibody-against-human-rhesus-cynomolgus-hla-dr","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-hla-dr-antibody-clone-l243-mouse-monoclonal-igg2a-antibody-against-human-rhesus-cynomolgus-hla-dr\/","title":{"rendered":"Anti-Human HLA-DR Antibody, Clone L243 Mouse monoclonal IgG2a antibody against human, rhesus, cynomolgus HLA-DR"},"content":{"rendered":"

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Overview<\/h3>\n
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The L243 antibody reacts with human HLA-DR, the major histocompatibility complex (MHC) class II receptor and a member of the immunoglobulin protein superfamily. HLA-DR is a heterodimeric transmembrane glycoprotein comprising a 36-kDa \u03b1 subunit associated non-covalently with a 27-kDa \u03b2 subunit and is expressed on the surface of antigen-presenting cells such as B cells, activated T cells, monocytes, macrophages and dendritic cells, activated natural killer (NK) cells, and progenitor cells. Together with the CD3\/T cell receptor (TCR) complex and CD4 molecules, HLA-DR mediates a critical function in presenting peptides generated from hydrolysis of exogenous antigens by antigen-presenting cells to CD4+T (helper) cells, thereby either suppressing or inducing an immune response to the peptides. Thus, HLA-DR is involved in graft-versus-host disease and several autoimmune conditions. The L243 antibody binds an extracellular, conformational, and nonpolymorphic epitope on the \u03b1 chain that is expressed only when the \u03b1\u03b2 heterodimer is correctly folded, and binding is not dependent on peptide loading of HLA-DR. Binding of the antibody blocks the association of HLA-DR with TCRs and reportedly exerts cytotoxic effects on human cells. The L243 antibody does not cross-react with HLA-DQ or HLA-DP.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: HLA-DR<\/div>\n<\/div>\n
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Alternative Names: HLA-DRA, Major histocompatibility class II, Major histocompatibility class II DR alpha, MHC class II, MHC class II DR alpha, MGC117330, MLRW<\/div>\n<\/div>\n
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Reactive Species: African Green Monkey; Baboon; Common Marmoset; Cotton-Topped Tamarin; Cynomolgus; Pigtailed Macaque; Rhesus; Squirrel Monkey; Chimpanzee; Dog; Human<\/div>\n<\/div>\n
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Conjugation: APC-Cyanine7; APC; FITC; PE<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: B Cells; Macrophages; Monocytes; T Cells<\/div>\n<\/div>\n
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Application: Flow Cytometry; Immunohistochemistry<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: L243<\/div>\n<\/div>\n
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Gene ID: 3122, 3123<\/div>\n<\/div>\n
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Isotype: IgG2a, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The L243 antibody reacts with human HLA-DR, the major histocompatibility complex (MHC) class II receptor and a member of the immunoglobulin protein superfamily. HLA-DR is a heterodimeric transmembrane glycoprotein comprising a 36-kDa \u03b1 subunit associated non-covalently with a 27-kDa \u03b2 subunit and is expressed on the surface of antigen-presenting cells such as B cells, activated T cells, monocytes, macrophages and dendritic cells, activated natural killer (NK) cells, and progenitor cells. Together with the CD3\/T cell receptor (TCR) complex and CD4 molecules, HLA-DR mediates a critical function in presenting peptides generated from hydrolysis of exogenous antigens by antigen-presenting cells to CD4+T (helper) cells, thereby either suppressing or inducing an immune response to the peptides. Thus, HLA-DR is involved in graft-versus-host disease and several autoimmune conditions. The L243 antibody binds an extracellular, conformational, and nonpolymorphic epitope on the \u03b1 chain that is expressed only when the \u03b1\u03b2 heterodimer is correctly folded, and binding is not dependent on peptide loading of HLA-DR. Binding of the antibody blocks the association of HLA-DR with TCRs and reportedly exerts cytotoxic effects on human cells. The L243 antibody does not cross-react with HLA-DQ or HLA-DP. Subtype: Primary Antibodies Target Antigen: HLA-DR Alternative Names: HLA-DRA, Major histocompatibility class II, Major histocompatibility class II DR alpha, MHC class II, MHC class II DR alpha, MGC117330, MLRW Reactive Species: African Green Monkey; Baboon; Common Marmoset; Cotton-Topped Tamarin; Cynomolgus; Pigtailed Macaque; Rhesus; Squirrel Monkey; Chimpanzee; Dog; Human Conjugation: APC-Cyanine7; APC; FITC; PE Host Species: Mouse Cell Type: B Cells; Macrophages; Monocytes; T Cells Application: Flow Cytometry; Immunohistochemistry Area of Interest: Immunology Clone: L243 Gene ID: 3122, 3123 Isotype: IgG2a, kappa<\/p>\n","protected":false},"featured_media":2583,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2582","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2582","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2583"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2582"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2582"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2582"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}