{"id":2585,"date":"2020-11-16T09:39:20","date_gmt":"2020-11-16T09:39:20","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2585"},"modified":"2020-11-16T09:39:20","modified_gmt":"2020-11-16T09:39:20","slug":"anti-mouse-cd152-ctla-4-antibody-clone-uc10-4f10-11-hamster-armenian-monoclonal-igg-antibody-against-mouse-cd152-ctla-4","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-cd152-ctla-4-antibody-clone-uc10-4f10-11-hamster-armenian-monoclonal-igg-antibody-against-mouse-cd152-ctla-4\/","title":{"rendered":"Anti-Mouse CD152 (CTLA-4) Antibody, Clone UC10-4F10-11 Hamster (Armenian) monoclonal IgG antibody against mouse CD152 (CTLA-4)"},"content":{"rendered":"

 <\/p>\n

\"\" \"\" \"\"<\/p>\n

Overview<\/h1>\n
\n
\n
The UC10-4F10-11 antibody reacts with an extracellular epitope on mouse CD152 (CTLA-4), a type I transmembrane glycoprotein receptor expressed on the surface of activated T and B cells and thymocytes. CD152 comprises a disulfide-linked homodimer of ~35 kDa subunits and is a member of the immunoglobulin protein superfamily. It functions as an antagonistic homolog of CD28 by binding the CD28 co-stimulatory ligands, CD80 and CD86. CD152 thereby acts to inhibit CD28-mediated stimulation during the early stages of T cell expansion. It also contributes to the suppressor function of T regulatory cells. CD152 has important roles in immunological tolerance and immunity, and mutations in its cognate gene have been associated with certain autoimmune disorders.<\/div>\n<\/div>\n<\/div>\n
<\/div>\n
\n
\n
\n
\n
\n
Subtype: Primary Antibodies<\/div>\n<\/div>\n
\n
Target Antigen: CD152 (CTLA-4)<\/div>\n<\/div>\n
\n
Alternative Names: CTLA-4, Cytotoxic T lymphocyte-associated antigen-4, Ly-56<\/div>\n<\/div>\n
\n
Reactive Species: Mouse<\/div>\n<\/div>\n
\n
Conjugation: APC; PE; Unconjugated<\/div>\n<\/div>\n
\n
Host Species: Hamster<\/div>\n<\/div>\n
\n
Cell Type: T Cells, Other Subsets<\/div>\n<\/div>\n
\n
Application: Flow Cytometry; Functional Assay; Immunoprecipitation<\/div>\n<\/div>\n
\n
Clone: UC10-4F10-11<\/div>\n<\/div>\n
\n
Gene ID: 12477<\/div>\n<\/div>\n
\n
Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The UC10-4F10-11 antibody reacts with an extracellular epitope on mouse CD152 (CTLA-4), a type I transmembrane glycoprotein receptor expressed on the surface of activated T and B cells and thymocytes. CD152 comprises a disulfide-linked homodimer of ~35 kDa subunits and is a member of the immunoglobulin protein superfamily. It functions as an antagonistic homolog of CD28 by binding the CD28 co-stimulatory ligands, CD80 and CD86. CD152 thereby acts to inhibit CD28-mediated stimulation during the early stages of T cell expansion. It also contributes to the suppressor function of T regulatory cells. CD152 has important roles in immunological tolerance and immunity, and mutations in its cognate gene have been associated with certain autoimmune disorders. Subtype: Primary Antibodies Target Antigen: CD152 (CTLA-4) Alternative Names: CTLA-4, Cytotoxic T lymphocyte-associated antigen-4, Ly-56 Reactive Species: Mouse Conjugation: APC; PE; Unconjugated Host Species: Hamster Cell Type: T Cells, Other Subsets Application: Flow Cytometry; Functional Assay; Immunoprecipitation Clone: UC10-4F10-11 Gene ID: 12477 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2585","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2585","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2585"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2585"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2585"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2585"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}