{"id":2594,"date":"2020-11-16T10:24:06","date_gmt":"2020-11-16T10:24:06","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2594"},"modified":"2020-11-16T10:24:06","modified_gmt":"2020-11-16T10:24:06","slug":"anti-mouse-cd11b-antibody-clone-m1-70-rat-monoclonal-igg2b-antibody-against-human-mouse-rhesus-cd11b","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-cd11b-antibody-clone-m1-70-rat-monoclonal-igg2b-antibody-against-human-mouse-rhesus-cd11b\/","title":{"rendered":"Anti-Mouse CD11b Antibody, Clone M1\/70 Rat monoclonal IgG2b antibody against human, mouse, rhesus CD11b"},"content":{"rendered":"

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Overview<\/h3>\n
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The M1\/70 antibody reacts with CD11b, an ~170 kDa type 1 transmembrane glycoprotein which associates non-covalently with CD18 to form the heterodimeric Mac-1 receptor. Through its interactions with ligands such as ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen, Mac-1 functions in several processes, including the adherence of neutrophils and monocytes to stimulated endothelium and phagocytosis of complement-coated particles. CD11b is expressed on the surface of granulocytes, monocytes, NK cells, dendritic cells, tissue macrophages, and subsets of T and B cells, and has been used as a marker to distinguish na\u00efve and memory CD8+ T cells. CD11b is a relatively late marker for myeloid differentiation and is undetectable on most myelomonocytic hematopoietic progenitor cells and more primitive cells. The M1\/70 antibody reportedly blocks iC3b binding to Mac-1. This antibody clone has been verified for purity assessments of cells isolated with EasySep\u2122 kits, including EasySep\u2122 Mouse Monocyte Isolation Kit.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD11b<\/div>\n<\/div>\n
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Alternative Names: alphaM integrin, C3biR, CR3, Ly-40, Mac-1, Mo1<\/div>\n<\/div>\n
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Reactive Species: Baboon; Rhesus; Chimpanzee; Human; Rabbit<\/div>\n<\/div>\n
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Conjugation: Biotin; FITC; PE; Unconjugated<\/div>\n<\/div>\n
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Host Species: Rat<\/div>\n<\/div>\n
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Cell Type: Granulocytes and Subsets; Monocytes<\/div>\n<\/div>\n
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Application: Cell Isolation; CyTOF; FACS; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Radioimmunoassay; Western Blotting<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: M1\/70<\/div>\n<\/div>\n
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Gene ID: 16409<\/div>\n<\/div>\n
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Isotype: IgG2b, kappa<\/div>\n
<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The M1\/70 antibody reacts with CD11b, an ~170 kDa type 1 transmembrane glycoprotein which associates non-covalently with CD18 to form the heterodimeric Mac-1 receptor. Through its interactions with ligands such as ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen, Mac-1 functions in several processes, including the adherence of neutrophils and monocytes to stimulated endothelium and phagocytosis of complement-coated particles. CD11b is expressed on the surface of granulocytes, monocytes, NK cells, dendritic cells, tissue macrophages, and subsets of T and B cells, and has been used as a marker to distinguish na\u00efve and memory CD8+ T cells. CD11b is a relatively late marker for myeloid differentiation and is undetectable on most myelomonocytic hematopoietic progenitor cells and more primitive cells. The M1\/70 antibody reportedly blocks iC3b binding to Mac-1. This antibody clone has been verified for purity assessments of cells isolated with EasySep\u2122 kits, including EasySep\u2122 Mouse Monocyte Isolation Kit. Subtype: Primary Antibodies Target Antigen: CD11b Alternative Names: alphaM integrin, C3biR, CR3, Ly-40, Mac-1, Mo1 Reactive Species: Baboon; Rhesus; Chimpanzee; Human; Rabbit Conjugation: Biotin; FITC; PE; Unconjugated Host Species: Rat Cell Type: Granulocytes and Subsets; Monocytes Application: Cell Isolation; CyTOF; FACS; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Radioimmunoassay; Western Blotting Area of Interest: Immunology Clone: M1\/70 Gene ID: 16409 Isotype: IgG2b, kappa<\/p>\n","protected":false},"featured_media":2574,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2594","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2574"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2594"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2594"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2594"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}