{"id":2597,"date":"2020-11-16T10:54:45","date_gmt":"2020-11-16T10:54:45","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2597"},"modified":"2020-11-16T10:55:42","modified_gmt":"2020-11-16T10:55:42","slug":"anti-mouse-nk1-1-cd161-antibody-clone-pk136-c3h-x-balb-c-f1-hybrid-monoclonal-igg2a-antibody-against-mouse-nk1-1-cd161","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-nk1-1-cd161-antibody-clone-pk136-c3h-x-balb-c-f1-hybrid-monoclonal-igg2a-antibody-against-mouse-nk1-1-cd161\/","title":{"rendered":"Anti-Mouse NK1.1 (CD161) Antibody, Clone PK136 (C3H x BALB\/c) F1 hybrid monoclonal IgG2a antibody against mouse NK1.1 (CD161)"},"content":{"rendered":"

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Overview<\/h3>\n
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The PK136 antibody reacts with murine NK1.1 (CD161), an ~80 kDa homodimeric type 2 transmembrane glycoprotein and C-type lectin receptor expressed on NK cells, NK-T cells, and rare subsets of T cells and monocytes in select strains of mice. NK1.1 is encoded by the Klrb1b and Klrb1c genes, which specify CD161b and CD161c polypeptides, respectively. CD161b is expressed only by Swiss NIH and SJL mice, and CD161c by certain strains such as C57BL, FVB\/N, and NZB (but not A, AKR, BALB\/c, CBA\/J, C3H, C57BR, C58, DBA\/1, DBA\/2, NOD, SJL, or 129). NK1.1 has functional roles in modulating several processes, including the activation and proliferation of NK cells, induction of interferon-\u03b3 production, and release of cytotoxic granules. Its expression on the cell surface is specifically upregulated by IL-12. For detection of NK cells in NK1.1- strains, Anti-Mouse CD49b Antibody, Clone DX5\u00a0 is recommended. DX5 recognizes CD49b (integrin \u03b12), another commonly used NK cell marker.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: NK1.1 (CD161)<\/div>\n<\/div>\n
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Alternative Names: CD161b, CD161c, Klrb1b, Klrb1c, Ly-55, Ly-59, NK-1.1, NKRP1, NKRP1a, NKRP1b<\/div>\n<\/div>\n
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Reactive Species: Mouse<\/div>\n<\/div>\n
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Conjugation: Biotin; FITC; PE; Unconjugated<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: NK Cells<\/div>\n<\/div>\n
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Application: Cell Isolation; CyTOF; Depletion; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: PK136<\/div>\n<\/div>\n
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Gene ID: 17059<\/div>\n<\/div>\n
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Isotype: IgG2a, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The PK136 antibody reacts with murine NK1.1 (CD161), an ~80 kDa homodimeric type 2 transmembrane glycoprotein and C-type lectin receptor expressed on NK cells, NK-T cells, and rare subsets of T cells and monocytes in select strains of mice. NK1.1 is encoded by the Klrb1b and Klrb1c genes, which specify CD161b and CD161c polypeptides, respectively. CD161b is expressed only by Swiss NIH and SJL mice, and CD161c by certain strains such as C57BL, FVB\/N, and NZB (but not A, AKR, BALB\/c, CBA\/J, C3H, C57BR, C58, DBA\/1, DBA\/2, NOD, SJL, or 129). NK1.1 has functional roles in modulating several processes, including the activation and proliferation of NK cells, induction of interferon-\u03b3 production, and release of cytotoxic granules. Its expression on the cell surface is specifically upregulated by IL-12. For detection of NK cells in NK1.1- strains, Anti-Mouse CD49b Antibody, Clone DX5\u00a0 is recommended. DX5 recognizes CD49b (integrin \u03b12), another commonly used NK cell marker. Subtype: Primary Antibodies Target Antigen: NK1.1 (CD161) Alternative Names: CD161b, CD161c, Klrb1b, Klrb1c, Ly-55, Ly-59, NK-1.1, NKRP1, NKRP1a, NKRP1b Reactive Species: Mouse Conjugation: Biotin; FITC; PE; Unconjugated Host Species: Mouse Cell Type: NK Cells Application: Cell Isolation; CyTOF; Depletion; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation Area of Interest: Immunology Clone: PK136 Gene ID: 17059 Isotype: IgG2a, kappa<\/p>\n","protected":false},"featured_media":2573,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2597","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2573"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2597"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2597"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2597"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}