{"id":2603,"date":"2020-11-17T08:09:37","date_gmt":"2020-11-17T08:09:37","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2603"},"modified":"2020-11-17T08:09:37","modified_gmt":"2020-11-17T08:09:37","slug":"anti-human-cd81-tapa-1-antibody-clone-5a6-mouse-monoclonal-antibody-against-human-rhesus-cynomolgus-cd81-unconjugated","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd81-tapa-1-antibody-clone-5a6-mouse-monoclonal-antibody-against-human-rhesus-cynomolgus-cd81-unconjugated\/","title":{"rendered":"Anti-Human CD81 (TAPA-1) Antibody, Clone 5A6 Mouse monoclonal antibody against human, rhesus, cynomolgus CD81, unconjugated"},"content":{"rendered":"

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Overview<\/h3>\n
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The 5A6 antibody reacts with an epitope located in the large extracellular loop (EC2) of human CD81 (TAPA-1). CD81 exhibits broad expression, including on the surface of B and T cells, NK cells, monocytes, dendritic cells, thymocytes, endothelial cells, and fibroblasts. It is also a marker characteristic of extracellular vesicles.<\/p>\n

CD81, a 26 kDa non-glycosylated type III transmembrane protein, belongs to the tetraspanin family. Tetraspanins contain four transmembrane domains, two extracellular loops, and short cytoplasmic N- and C-termini. CD81 associates with numerous integrins, co-receptors, and other proteins to form multimolecular complexes in the plasma membrane called tetraspanin-enriched microdomains. Palmitoylation of the juxtamembrane cysteine residues is important for its association with other proteins and the plasma membrane.<\/p>\n

CD81 modulates a diverse array of biological functions including cell-cell adhesion and fusion, cell migration, and proliferation. For example, together with CD19 and CD21, CD81 forms a co-receptor for the B cell receptor on B cells. The epitope of the 5A6 antibody is hidden when CD81 is in complex with CD19 but accessible following activation of the B cell. Mutations in CD81 have been associated with the immune disorder common variable immunodeficiency (CVID). CD81 has also been implicated in mediating the entry of hepatitis C virus into cells.<\/p><\/div>\n<\/div>\n<\/div>\n

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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD81<\/div>\n<\/div>\n
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Alternative Names: CVID6<\/div>\n<\/div>\n
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Reactive Species: African Green Monkey; Baboon; Cynomolgus; Rhesus; Chimpanzee; Human<\/div>\n<\/div>\n
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Conjugation: Unconjugated<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: Other<\/div>\n<\/div>\n
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Application: Flow Cytometry; Western Blotting<\/div>\n<\/div>\n
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Area of Interest: Extracellular Vesicle Research<\/div>\n<\/div>\n
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Clone: 5A6<\/div>\n<\/div>\n
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Gene ID: 975<\/div>\n<\/div>\n
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Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The 5A6 antibody reacts with an epitope located in the large extracellular loop (EC2) of human CD81 (TAPA-1). CD81 exhibits broad expression, including on the surface of B and T cells, NK cells, monocytes, dendritic cells, thymocytes, endothelial cells, and fibroblasts. It is also a marker characteristic of extracellular vesicles. CD81, a 26 kDa non-glycosylated type III transmembrane protein, belongs to the tetraspanin family. Tetraspanins contain four transmembrane domains, two extracellular loops, and short cytoplasmic N- and C-termini. CD81 associates with numerous integrins, co-receptors, and other proteins to form multimolecular complexes in the plasma membrane called tetraspanin-enriched microdomains. Palmitoylation of the juxtamembrane cysteine residues is important for its association with other proteins and the plasma membrane. CD81 modulates a diverse array of biological functions including cell-cell adhesion and fusion, cell migration, and proliferation. For example, together with CD19 and CD21, CD81 forms a co-receptor for the B cell receptor on B cells. The epitope of the 5A6 antibody is hidden when CD81 is in complex with CD19 but accessible following activation of the B cell. Mutations in CD81 have been associated with the immune disorder common variable immunodeficiency (CVID). CD81 has also been implicated in mediating the entry of hepatitis C virus into cells. Subtype: Primary Antibodies Target Antigen: CD81 Alternative Names: CVID6 Reactive Species: African Green Monkey; Baboon; Cynomolgus; Rhesus; Chimpanzee; Human Conjugation: Unconjugated Host Species: Mouse Cell Type: Other Application: Flow Cytometry; Western Blotting Area of Interest: Extracellular Vesicle Research Clone: 5A6 Gene ID: 975 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2603","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2603","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2603"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2603"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2603"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}