{"id":2614,"date":"2020-11-17T11:47:07","date_gmt":"2020-11-17T11:47:07","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2614"},"modified":"2020-11-17T11:47:07","modified_gmt":"2020-11-17T11:47:07","slug":"anti-human-cd105-antibody-clone-43a3-mouse-monoclonal-igg1-antibody-against-human-mouse-cd105-endoglin","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd105-antibody-clone-43a3-mouse-monoclonal-igg1-antibody-against-human-mouse-cd105-endoglin\/","title":{"rendered":"Anti-Human CD105 Antibody, Clone 43A3 Mouse monoclonal IgG1 antibody against human, mouse CD105 (endoglin)"},"content":{"rendered":"

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Overview<\/h3>\n
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The 43A3 antibody reacts with CD105 (endoglin), an ~180 kDa cell surface glycoprotein which is a disulfide-bonded homodimer of ~90 kDa type I transmembrane subunits. CD105 is a component of the TGF-\u03b2 receptor complex and is expressed by vascular endothelial smooth muscle cells, syncytiotrophoblasts of placenta and activated macrophages, and at relatively low levels by stromal fibroblasts. Its expression is also observed in some types of tumors, and levels are up-regulated on the endothelium during angiogenesis. In concert with signaling receptors, CD105 binds to TGF-\u03b21 and TGF-\u03b23 with high affinity, but does not bind TGF-\u03b22. Other ligands reportedly include Activin A, BMP-2, and BMP-7. CD105 has important roles in angiogenesis, cardiovascular development, and vascular remodeling, and the protein serves a regulatory role in cytoskeletal reorganization by modulating the sites of focal adhesion and cellular migration. Certain mutations in CD105 result in the autosomal dominant disorder hereditary hemorrhagic telangiectasia.<\/p>\n

This antibody clone has been verified for labeling human mesenchymal cells grown in MesenCult\u2122 Proliferation Kit (Human; Catalog #05411) and MesenCult\u2122-XF Medium<\/p><\/div>\n<\/div>\n<\/div>\n

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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD105 (Endoglin)<\/div>\n<\/div>\n
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Alternative Names: Endoglin<\/div>\n<\/div>\n
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Reactive Species: Human; Mouse<\/div>\n<\/div>\n
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Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; Unconjugated<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: Hematopoietic Stem and Progenitor Cells; Mesenchymal Stem and Progenitor Cells<\/div>\n<\/div>\n
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Application: Flow Cytometry; Immunoprecipitation; Western Blotting<\/div>\n<\/div>\n
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Area of Interest: Endothelial Cell Biology; Stem Cell Biology<\/div>\n<\/div>\n
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Clone: 43A3<\/div>\n<\/div>\n
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Gene ID: 2022<\/div>\n<\/div>\n
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Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The 43A3 antibody reacts with CD105 (endoglin), an ~180 kDa cell surface glycoprotein which is a disulfide-bonded homodimer of ~90 kDa type I transmembrane subunits. CD105 is a component of the TGF-\u03b2 receptor complex and is expressed by vascular endothelial smooth muscle cells, syncytiotrophoblasts of placenta and activated macrophages, and at relatively low levels by stromal fibroblasts. Its expression is also observed in some types of tumors, and levels are up-regulated on the endothelium during angiogenesis. In concert with signaling receptors, CD105 binds to TGF-\u03b21 and TGF-\u03b23 with high affinity, but does not bind TGF-\u03b22. Other ligands reportedly include Activin A, BMP-2, and BMP-7. CD105 has important roles in angiogenesis, cardiovascular development, and vascular remodeling, and the protein serves a regulatory role in cytoskeletal reorganization by modulating the sites of focal adhesion and cellular migration. Certain mutations in CD105 result in the autosomal dominant disorder hereditary hemorrhagic telangiectasia. This antibody clone has been verified for labeling human mesenchymal cells grown in MesenCult\u2122 Proliferation Kit (Human; Catalog #05411) and MesenCult\u2122-XF Medium Subtype: Primary Antibodies Target Antigen: CD105 (Endoglin) Alternative Names: Endoglin Reactive Species: Human; Mouse Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; Unconjugated Host Species: Mouse Cell Type: Hematopoietic Stem and Progenitor Cells; Mesenchymal Stem and Progenitor Cells Application: Flow Cytometry; Immunoprecipitation; Western Blotting Area of Interest: Endothelial Cell Biology; Stem Cell Biology Clone: 43A3 Gene ID: 2022 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2579,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2614","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2579"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2614"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2614"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2614"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}