{"id":2616,"date":"2020-11-17T13:24:08","date_gmt":"2020-11-17T13:24:08","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2616"},"modified":"2020-11-17T13:24:08","modified_gmt":"2020-11-17T13:24:08","slug":"anti-human-cd11b-antibody-clone-icrf44-mouse-monoclonal-igg1-antibody-against-human-rhesus-cynomolgus-cd11b","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd11b-antibody-clone-icrf44-mouse-monoclonal-igg1-antibody-against-human-rhesus-cynomolgus-cd11b\/","title":{"rendered":"Anti-Human CD11b Antibody, Clone ICRF44 Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD11b"},"content":{"rendered":"

\"\" \"\"<\/p>\n

 <\/p>\n

Overview<\/h3>\n
\n
\n
The ICRF44 antibody reacts with an extracellular epitope on CD11b (integrin \u03b1M), an ~170 kDa type 1 transmembrane glycoprotein which associates non-covalently with CD18 to form the heterodimeric Mac-1 receptor. Through its interactions with ligands such as ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, heparin, and fibrinogen, Mac-1 influences several processes, including the adherence of neutrophils and monocytes to stimulated endothelium, and phagocytosis of complement-coated particles. CD11b is expressed on the surface of granulocytes, monocytes, NK cells, dendritic cells, tissue macrophages, and subsets of T and B cells, and has been used as a marker to distinguish na\u00efve and memory CD8+ T cells. CD11b is a relatively late marker for myeloid differentiation, and is undetectable on most myelomonocytic hematopoietic progenitor cells and more primitive cells. Certain mutations in CD11b give rise to the disorder systemic lupus erythematosus. The ICRF44 antibody reportedly inhibits leukocyte aggregation in response to the chemoattractant fMLP.<\/p>\n

This antibody clone has been verified for purity assessments of cells isolated with EasySep\u2122 kits, including EasySep\u2122 Human Monocyte Enrichment Kit (Catalog #19059), and for labeling human mesenchymal cells grown in MesenCult\u2122 Proliferation Kit<\/p><\/div>\n<\/div>\n<\/div>\n

<\/div>\n
\n
\n
\n
\n
\n
Subtype: Primary Antibodies<\/div>\n<\/div>\n
\n
Target Antigen: CD11b<\/div>\n<\/div>\n
\n
Alternative Names: C3biR, CR3, Integrin \u03b1M chain, Mac-1, MAC1, Mo1<\/div>\n<\/div>\n
\n
Reactive Species: Baboon; Common Marmoset; Cynomolgus; Rhesus; Chimpanzee; Human; Pig<\/div>\n<\/div>\n
\n
Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; Unconjugated<\/div>\n<\/div>\n
\n
Host Species: Mouse<\/div>\n<\/div>\n
\n
Cell Type: Myeloid Cells<\/div>\n<\/div>\n
\n
Application: Cell Isolation; CyTOF; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Western Blotting<\/div>\n<\/div>\n
\n
Area of Interest: Immunology<\/div>\n<\/div>\n
\n
Clone: ICRF44<\/div>\n<\/div>\n
\n
Gene ID: 3684<\/div>\n<\/div>\n
\n
Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The ICRF44 antibody reacts with an extracellular epitope on CD11b (integrin \u03b1M), an ~170 kDa type 1 transmembrane glycoprotein which associates non-covalently with CD18 to form the heterodimeric Mac-1 receptor. Through its interactions with ligands such as ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, heparin, and fibrinogen, Mac-1 influences several processes, including the adherence of neutrophils and monocytes to stimulated endothelium, and phagocytosis of complement-coated particles. CD11b is expressed on the surface of granulocytes, monocytes, NK cells, dendritic cells, tissue macrophages, and subsets of T and B cells, and has been used as a marker to distinguish na\u00efve and memory CD8+ T cells. CD11b is a relatively late marker for myeloid differentiation, and is undetectable on most myelomonocytic hematopoietic progenitor cells and more primitive cells. Certain mutations in CD11b give rise to the disorder systemic lupus erythematosus. The ICRF44 antibody reportedly inhibits leukocyte aggregation in response to the chemoattractant fMLP. This antibody clone has been verified for purity assessments of cells isolated with EasySep\u2122 kits, including EasySep\u2122 Human Monocyte Enrichment Kit (Catalog #19059), and for labeling human mesenchymal cells grown in MesenCult\u2122 Proliferation Kit Subtype: Primary Antibodies Target Antigen: CD11b Alternative Names: C3biR, CR3, Integrin \u03b1M chain, Mac-1, MAC1, Mo1 Reactive Species: Baboon; Common Marmoset; Cynomolgus; Rhesus; Chimpanzee; Human; Pig Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; Unconjugated Host Species: Mouse Cell Type: Myeloid Cells Application: Cell Isolation; CyTOF; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Western Blotting Area of Interest: Immunology Clone: ICRF44 Gene ID: 3684 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2616","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2616"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2616"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2616"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}