{"id":2617,"date":"2020-11-17T13:26:46","date_gmt":"2020-11-17T13:26:46","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2617"},"modified":"2020-11-17T13:41:16","modified_gmt":"2020-11-17T13:41:16","slug":"anti-human-cd123-il-3r%ce%b1-antibody-clone-6h6-mouse-monoclonal-igg1-antibody-against-human-rhesus-sooty-mangabey-cd123-il-3r%ce%b1","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd123-il-3r%ce%b1-antibody-clone-6h6-mouse-monoclonal-igg1-antibody-against-human-rhesus-sooty-mangabey-cd123-il-3r%ce%b1\/","title":{"rendered":"Anti-Human CD123 (IL-3R\u03b1) Antibody, Clone 6H6 Mouse monoclonal IgG1 antibody against human, rhesus, sooty mangabey CD123 (IL-3R\u03b1)"},"content":{"rendered":"

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Overview<\/h3>\n
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The 6H6 antibody reacts with human CD123 (IL-3 receptor subunit \u03b1), an ~70 kDa type I transmembrane glycoprotein belonging to the type I cytokine receptor family (type 5 subfamily) and the immunoglobulin (Ig) superfamily. CD123 constitutes the ligand-binding \u03b1 chain of the heterodimeric IL-3 receptor. CD123 binds IL-3 with low affinity per se, but when associated with CD131 (the signal-transducing \u03b2 chain of the receptor), high-affinity binding of IL-3 is observed. CD123 is expressed by hematopoietic progenitor cells, endothelial cells, basophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells, megakaryocytes, a subset of B cells, and by neutrophils if cultured in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-3 binding to CD123 stimulates proliferation, differentiation, and viability of hematopoietic cells. CD123 is highly expressed in malignancies such as acute leukemia. The 6H6 antibody does not inhibit binding of IL-3 to either CD123 or the IL-3 receptor.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD123 (IL-3R\u03b1)<\/div>\n<\/div>\n
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Alternative Names: hIL-3Ra, IL3R, IL3RAX, IL3RAY, IL3RX, IL3RY, IL-3Ra, IL-3 receptor alpha SP2 isoform, Interleukin-3 Receptor alpha, MGC34174<\/div>\n<\/div>\n
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Reactive Species: Human; Rhesus; Sooty Mangabey<\/div>\n<\/div>\n
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Conjugation: APC; Biotin; FITC; PE; Unconjugated; PerCP-Cyanine5.5<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: Granulocytes and Subsets; Dendritic Cells; Hematopoietic Stem and Progenitor Cells; Myeloid Cells<\/div>\n<\/div>\n
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Application: Flow Cytometry; Functional Assay; Immunofluorescence; Immunocytochemistry; Immunohistochemistry; Immunoprecipitation; CyTOF; Western Blotting<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: 6H6<\/div>\n<\/div>\n
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Gene ID: 3563<\/div>\n<\/div>\n
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Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The 6H6 antibody reacts with human CD123 (IL-3 receptor subunit \u03b1), an ~70 kDa type I transmembrane glycoprotein belonging to the type I cytokine receptor family (type 5 subfamily) and the immunoglobulin (Ig) superfamily. CD123 constitutes the ligand-binding \u03b1 chain of the heterodimeric IL-3 receptor. CD123 binds IL-3 with low affinity per se, but when associated with CD131 (the signal-transducing \u03b2 chain of the receptor), high-affinity binding of IL-3 is observed. CD123 is expressed by hematopoietic progenitor cells, endothelial cells, basophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells, megakaryocytes, a subset of B cells, and by neutrophils if cultured in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-3 binding to CD123 stimulates proliferation, differentiation, and viability of hematopoietic cells. CD123 is highly expressed in malignancies such as acute leukemia. The 6H6 antibody does not inhibit binding of IL-3 to either CD123 or the IL-3 receptor. Subtype: Primary Antibodies Target Antigen: CD123 (IL-3R\u03b1) Alternative Names: hIL-3Ra, IL3R, IL3RAX, IL3RAY, IL3RX, IL3RY, IL-3Ra, IL-3 receptor alpha SP2 isoform, Interleukin-3 Receptor alpha, MGC34174 Reactive Species: Human; Rhesus; Sooty Mangabey Conjugation: APC; Biotin; FITC; PE; Unconjugated; PerCP-Cyanine5.5 Host Species: Mouse Cell Type: Granulocytes and Subsets; Dendritic Cells; Hematopoietic Stem and Progenitor Cells; Myeloid Cells Application: Flow Cytometry; Functional Assay; Immunofluorescence; Immunocytochemistry; Immunohistochemistry; Immunoprecipitation; CyTOF; Western Blotting Area of Interest: Immunology Clone: 6H6 Gene ID: 3563 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2579,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2617","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2617","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2579"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2617"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2617"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2617"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}