{"id":2621,"date":"2020-11-17T13:59:12","date_gmt":"2020-11-17T13:59:12","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2621"},"modified":"2020-11-17T13:59:12","modified_gmt":"2020-11-17T13:59:12","slug":"anti-human-cd14-antibody-clone-mop9-mouse-monoclonal-igg2b-antibody-against-human-rhesus-cynomolgus-cd14","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd14-antibody-clone-mop9-mouse-monoclonal-igg2b-antibody-against-human-rhesus-cynomolgus-cd14\/","title":{"rendered":"Anti-Human CD14 Antibody, Clone MoP9 Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD14"},"content":{"rendered":"

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Overview<\/h3>\n

The MoP9 antibody reacts with CD14, a 53 – 55 kDa glycosylphosphatidylinositol (GPI)-anchored transmembrane glycoprotein expressed at high levels on the surface of peripheral blood monocytes and macrophages, and at lower levels on granulocytes. An approximate 10-fold difference in expression levels between monocytes\/macrophages and granulocytes makes CD14 a useful marker for distinguishing these cell populations. CD14 is also found on tissue macrophages, Langerhans cells, and dendritic cells. CD14 functions as a high-affinity receptor for complexes of lipopolysaccharide (LPS) and serum LPS-binding protein and modulates LPS-dependent signal transduction during the immune response to gram-negative pathogens by acting as a co-receptor for TLR 4 and MD-2. This triggers activation of NF-\u03baB, cytokine secretion, and induction of the inflammatory response. Two soluble forms of CD14 have also been described (~48 and ~55 kDa).<\/p>\n

 <\/p>\n

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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD14<\/div>\n<\/div>\n
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Alternative Names: LPS receptor<\/div>\n<\/div>\n
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Reactive Species: Human<\/div>\n<\/div>\n
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Conjugation: FITC<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: Monocytes<\/div>\n<\/div>\n
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Application: Cell Isolation; Flow Cytometry<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: MoP9<\/div>\n<\/div>\n
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Gene ID: 929<\/div>\n<\/div>\n
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Isotype: IgG2b, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The MoP9 antibody reacts with CD14, a 53 – 55 kDa glycosylphosphatidylinositol (GPI)-anchored transmembrane glycoprotein expressed at high levels on the surface of peripheral blood monocytes and macrophages, and at lower levels on granulocytes. An approximate 10-fold difference in expression levels between monocytes\/macrophages and granulocytes makes CD14 a useful marker for distinguishing these cell populations. CD14 is also found on tissue macrophages, Langerhans cells, and dendritic cells. CD14 functions as a high-affinity receptor for complexes of lipopolysaccharide (LPS) and serum LPS-binding protein and modulates LPS-dependent signal transduction during the immune response to gram-negative pathogens by acting as a co-receptor for TLR 4 and MD-2. This triggers activation of NF-\u03baB, cytokine secretion, and induction of the inflammatory response. Two soluble forms of CD14 have also been described (~48 and ~55 kDa).   Subtype: Primary Antibodies Target Antigen: CD14 Alternative Names: LPS receptor Reactive Species: Human Conjugation: FITC Host Species: Mouse Cell Type: Monocytes Application: Cell Isolation; Flow Cytometry Area of Interest: Immunology Clone: MoP9 Gene ID: 929 Isotype: IgG2b, kappa<\/p>\n","protected":false},"featured_media":2563,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2621","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2621","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2563"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2621"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2621"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2621"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}