{"id":2623,"date":"2020-11-17T14:27:32","date_gmt":"2020-11-17T14:27:32","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2623"},"modified":"2020-11-17T14:27:32","modified_gmt":"2020-11-17T14:27:32","slug":"anti-human-cd184-cxcr4-antibody-clone-12g5-mouse-monoclonal-igg2a-antibody-against-human-rhesus-cynomolgus-cd184-cxcr4","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd184-cxcr4-antibody-clone-12g5-mouse-monoclonal-igg2a-antibody-against-human-rhesus-cynomolgus-cd184-cxcr4\/","title":{"rendered":"Anti-Human CD184 (CXCR4) Antibody, Clone 12G5 Mouse monoclonal IgG2a antibody against human, rhesus, cynomolgus CD184 (CXCR4)"},"content":{"rendered":"

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Overview<\/h3>\n
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The 12G5 antibody reacts with CD184 (CXCR4 or fusin), an ~45 kDa seven transmembrane G-protein-coupled receptor expressed on the surface of a broad range of cells, including T and B cells, dendritic cells, monocytes, macrophages, granulocytes, platelets, endothelial and epithelial cells, astrocytes and neurons. At least two isoforms of CD184 are generated by alternate mRNA splicing. Ligands for CD184 include the CXC chemokine SDF-1 and ubiquitin. CD184 has functional roles in mediating chemotaxis, B cell lymphopoiesis and myelopoiesis, cardiogenesis, vascularization and neuronal guidance. CD184 acts as a co-receptor for infection by some T cell-tropic isolates of HIV-1 and as an alternative receptor for CD4-independent infection by HIV-2; functions that are blocked by binding of the 12G5 antibody. The antibody also partially inhibits SDF-1-induced chemotaxis and calcium influx. In differentiation studies, CD184 is used along with other markers such as CD117 to monitor the emergence of definitive endoderm.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD184 (CXCR4)<\/div>\n<\/div>\n
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Alternative Names: C-X-C chemokine receptor type 4, CXCR4, fusin, HM89, HUMSTR, LAP3, LCR1, LESTR, NPYY3R, NPY3R, SDF-1 receptor, WHIM<\/div>\n<\/div>\n
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Reactive Species: African Green Monkey; Human; Rhesus; Cynomolgus; Baboon; Chimpanzee; Sooty Mangabey<\/div>\n<\/div>\n
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Conjugation: Unconjugated; PE; APC; Biotin<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: Pluripotent Stem Cells; Endoderm, PSC-Derived<\/div>\n<\/div>\n
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Application: Functional Assay; CyTOF; Flow Cytometry; Immunocytochemistry; Immunofluorescence; Immunohistochemistry<\/div>\n<\/div>\n
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Area of Interest: Stem Cell Biology; Immunology<\/div>\n<\/div>\n
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Clone: 12G5<\/div>\n<\/div>\n
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Gene ID: 7852<\/div>\n<\/div>\n
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Isotype: IgG2a, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The 12G5 antibody reacts with CD184 (CXCR4 or fusin), an ~45 kDa seven transmembrane G-protein-coupled receptor expressed on the surface of a broad range of cells, including T and B cells, dendritic cells, monocytes, macrophages, granulocytes, platelets, endothelial and epithelial cells, astrocytes and neurons. At least two isoforms of CD184 are generated by alternate mRNA splicing. Ligands for CD184 include the CXC chemokine SDF-1 and ubiquitin. CD184 has functional roles in mediating chemotaxis, B cell lymphopoiesis and myelopoiesis, cardiogenesis, vascularization and neuronal guidance. CD184 acts as a co-receptor for infection by some T cell-tropic isolates of HIV-1 and as an alternative receptor for CD4-independent infection by HIV-2; functions that are blocked by binding of the 12G5 antibody. The antibody also partially inhibits SDF-1-induced chemotaxis and calcium influx. In differentiation studies, CD184 is used along with other markers such as CD117 to monitor the emergence of definitive endoderm. Subtype: Primary Antibodies Target Antigen: CD184 (CXCR4) Alternative Names: C-X-C chemokine receptor type 4, CXCR4, fusin, HM89, HUMSTR, LAP3, LCR1, LESTR, NPYY3R, NPY3R, SDF-1 receptor, WHIM Reactive Species: African Green Monkey; Human; Rhesus; Cynomolgus; Baboon; Chimpanzee; Sooty Mangabey Conjugation: Unconjugated; PE; APC; Biotin Host Species: Mouse Cell Type: Pluripotent Stem Cells; Endoderm, PSC-Derived Application: Functional Assay; CyTOF; Flow Cytometry; Immunocytochemistry; Immunofluorescence; Immunohistochemistry Area of Interest: Stem Cell Biology; Immunology Clone: 12G5 Gene ID: 7852 Isotype: IgG2a, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2623","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2623"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2623"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2623"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}