{"id":2625,"date":"2020-11-17T14:38:51","date_gmt":"2020-11-17T14:38:51","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2625"},"modified":"2020-11-17T14:38:51","modified_gmt":"2020-11-17T14:38:51","slug":"anti-human-cd22-antibody-clone-hib22-mouse-monoclonal-igg1-antibody-against-human-chimpanzee-cd22","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd22-antibody-clone-hib22-mouse-monoclonal-igg1-antibody-against-human-chimpanzee-cd22\/","title":{"rendered":"Anti-Human CD22 Antibody, Clone HIB22 Mouse monoclonal IgG1 antibody against human, chimpanzee CD22"},"content":{"rendered":"

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Overview<\/h3>\n
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The HIB22 antibody reacts with CD22 (Siglec-2), a type I transmembrane glycoprotein expressed in the cytoplasm of pro-B and pre-B cells and on the surface of mature and activated B cells and B cell lymphomas, but not on plasma cells. CD22 functions as an inhibitory receptor for B cell receptor signaling and plays roles in modulating the activation threshold of B cells and controlling CD40 signaling. CD22 comprises two isoforms generated by alternative splicing: CD22\u03b1 (~130 kDa) and CD22\u03b2 (~140 kDa). Monomeric CD22\u03b2 is the most abundant isoform but an \u03b1\u03b2 heterodimer is also expressed. CD22 is a member of the sialoadhesion subgroup within the immunoglobulin superfamily, with an N-terminal V-type Ig domain followed by six C2-type Ig domains. Binding of the HIB22 antibody reportedly requires the presence of the two N-terminal-most domains. Both the cytoplasmic and surface-bound forms of CD22 are recognized by the HIB22 antibody and its binding does not inhibit CD22-mediated cyto-adhesion.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD22<\/div>\n<\/div>\n
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Alternative Names: B-lymphocyte cell adhesion molecule, BLCAM, Leu-14, Lyb8, Sialic acid-binding Ig-like lectin 2, Siglec-2<\/div>\n<\/div>\n
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Reactive Species: Chimpanzee; Human<\/div>\n<\/div>\n
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Conjugation: APC; FITC; PE; Unconjugated<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: B Cells<\/div>\n<\/div>\n
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Application: ELISA; Functional Assay; Flow Cytometry; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: HIB22<\/div>\n<\/div>\n
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Gene ID: 933<\/div>\n<\/div>\n
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Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The HIB22 antibody reacts with CD22 (Siglec-2), a type I transmembrane glycoprotein expressed in the cytoplasm of pro-B and pre-B cells and on the surface of mature and activated B cells and B cell lymphomas, but not on plasma cells. CD22 functions as an inhibitory receptor for B cell receptor signaling and plays roles in modulating the activation threshold of B cells and controlling CD40 signaling. CD22 comprises two isoforms generated by alternative splicing: CD22\u03b1 (~130 kDa) and CD22\u03b2 (~140 kDa). Monomeric CD22\u03b2 is the most abundant isoform but an \u03b1\u03b2 heterodimer is also expressed. CD22 is a member of the sialoadhesion subgroup within the immunoglobulin superfamily, with an N-terminal V-type Ig domain followed by six C2-type Ig domains. Binding of the HIB22 antibody reportedly requires the presence of the two N-terminal-most domains. Both the cytoplasmic and surface-bound forms of CD22 are recognized by the HIB22 antibody and its binding does not inhibit CD22-mediated cyto-adhesion. Subtype: Primary Antibodies Target Antigen: CD22 Alternative Names: B-lymphocyte cell adhesion molecule, BLCAM, Leu-14, Lyb8, Sialic acid-binding Ig-like lectin 2, Siglec-2 Reactive Species: Chimpanzee; Human Conjugation: APC; FITC; PE; Unconjugated Host Species: Mouse Cell Type: B Cells Application: ELISA; Functional Assay; Flow Cytometry; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation Area of Interest: Immunology Clone: HIB22 Gene ID: 933 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2625","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2625"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2625"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2625"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}