{"id":2626,"date":"2020-11-17T14:40:59","date_gmt":"2020-11-17T14:40:59","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2626"},"modified":"2020-11-17T14:40:59","modified_gmt":"2020-11-17T14:40:59","slug":"anti-human-cd235a-glycophorin-a-antibody-clone-2b7-mouse-monoclonal-igg1-antibody-against-human-cd235a-glycophorin-a","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd235a-glycophorin-a-antibody-clone-2b7-mouse-monoclonal-igg1-antibody-against-human-cd235a-glycophorin-a\/","title":{"rendered":"Anti-Human CD235a (Glycophorin A) Antibody, Clone 2B7 Mouse monoclonal IgG1 antibody against human CD235a (glycophorin A)"},"content":{"rendered":"

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Overview<\/h3>\n
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The 2B7 antibody reacts with CD235a (Glycophorin A), an ~10 kDa type I sialoglycoprotein present in the cell membrane of erythrocytes and erythroid precursors as a homodimer. Glycophorin A bears the antigenic determinants for the MN and Ss blood groups and has been proposed to provide a large mucin-like surface to erythrocytes that acts to minimize aggregation in circulation. Glycophorin A is first detectable on morphologically recognizable erythroid precursors just after the colony-forming unit erythroid (CFU-E) stage, and reaches its maximal expression at the late normoblast stage. Anti-glycophorin is useful in combination with anti-transferrin receptor (CD71) to identify distinct stages of erythroid differentiation since CD71 expression precedes Glycophorin A expression, but is lost during maturation of normoblasts into mature red blood cells (RBCs). Peptide-binding ELISA data indicate that the epitope of the 2B7 antibody is located in the extracellular domain of CD235a within the sequence Ala54 – Ser66 (AATPRAHEVSEIS).<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD235 (Glycophorin)<\/div>\n<\/div>\n
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Alternative Names: Glycophorin A, GYPA, MN sialoglycoprotein, MNS blood group, PAS-2, Sialoglycoprotein alpha<\/div>\n<\/div>\n
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Reactive Species: Human<\/div>\n<\/div>\n
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Conjugation: FITC<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: Erythroid Cells; Red Blood Cells<\/div>\n<\/div>\n
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Application: Cell Isolation; Flow Cytometry<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: 2B7<\/div>\n<\/div>\n
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Gene ID: 2993<\/div>\n<\/div>\n
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Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The 2B7 antibody reacts with CD235a (Glycophorin A), an ~10 kDa type I sialoglycoprotein present in the cell membrane of erythrocytes and erythroid precursors as a homodimer. Glycophorin A bears the antigenic determinants for the MN and Ss blood groups and has been proposed to provide a large mucin-like surface to erythrocytes that acts to minimize aggregation in circulation. Glycophorin A is first detectable on morphologically recognizable erythroid precursors just after the colony-forming unit erythroid (CFU-E) stage, and reaches its maximal expression at the late normoblast stage. Anti-glycophorin is useful in combination with anti-transferrin receptor (CD71) to identify distinct stages of erythroid differentiation since CD71 expression precedes Glycophorin A expression, but is lost during maturation of normoblasts into mature red blood cells (RBCs). Peptide-binding ELISA data indicate that the epitope of the 2B7 antibody is located in the extracellular domain of CD235a within the sequence Ala54 – Ser66 (AATPRAHEVSEIS). Subtype: Primary Antibodies Target Antigen: CD235 (Glycophorin) Alternative Names: Glycophorin A, GYPA, MN sialoglycoprotein, MNS blood group, PAS-2, Sialoglycoprotein alpha Reactive Species: Human Conjugation: FITC Host Species: Mouse Cell Type: Erythroid Cells; Red Blood Cells Application: Cell Isolation; Flow Cytometry Area of Interest: Immunology Clone: 2B7 Gene ID: 2993 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2579,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2626","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2626","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2579"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2626"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2626"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2626"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2626"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}