{"id":2633,"date":"2020-11-18T10:05:19","date_gmt":"2020-11-18T10:05:19","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2633"},"modified":"2020-11-18T10:05:19","modified_gmt":"2020-11-18T10:05:19","slug":"anti-human-cd3-antibody-clone-sk7-mouse-monoclonal-igg1-antibody-against-human-chimpanzee-cd3","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd3-antibody-clone-sk7-mouse-monoclonal-igg1-antibody-against-human-chimpanzee-cd3\/","title":{"rendered":"Anti-Human CD3 Antibody, Clone SK7 Mouse monoclonal IgG1 antibody against human, chimpanzee CD3"},"content":{"rendered":"

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Overview<\/h3>\n
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The SK7 antibody reacts with the ~20 kDa CD3\u03b5 subunit of the human T cell receptor (TCR)\/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NKT cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex, which is assembled from combinations of CD3\u03b3, \u03b4, \u03b5, \u03b7 and \u03b6 subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders, including severe combined immunodeficiency (SCID).<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD3<\/div>\n<\/div>\n
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Reactive Species: Human; Chimpanzee<\/div>\n<\/div>\n
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Conjugation: FITC<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: T Cells<\/div>\n<\/div>\n
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Application: Cell Isolation; Flow Cytometry<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The SK7 antibody reacts with the ~20 kDa CD3\u03b5 subunit of the human T cell receptor (TCR)\/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NKT cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex, which is assembled from combinations of CD3\u03b3, \u03b4, \u03b5, \u03b7 and \u03b6 subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders, including severe combined immunodeficiency (SCID). Subtype: Primary Antibodies Target Antigen: CD3 Reactive Species: Human; Chimpanzee Conjugation: FITC Host Species: Mouse Cell Type: T Cells Application: Cell Isolation; Flow Cytometry Area of Interest: Immunology<\/p>\n","protected":false},"featured_media":2572,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2633","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2572"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2633"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2633"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2633"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}