{"id":2634,"date":"2020-11-18T10:08:45","date_gmt":"2020-11-18T10:08:45","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2634"},"modified":"2020-11-18T10:08:45","modified_gmt":"2020-11-18T10:08:45","slug":"anti-human-cd3-antibody-clone-ucht1-mouse-balb-c-monoclonal-igg1-antibody-against-human-chimpanzee-cd3","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd3-antibody-clone-ucht1-mouse-balb-c-monoclonal-igg1-antibody-against-human-chimpanzee-cd3\/","title":{"rendered":"Anti-Human CD3 Antibody, Clone UCHT1 Mouse (BALB\/c) monoclonal IgG1 antibody against human, chimpanzee CD3"},"content":{"rendered":"

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Overview<\/h3>\n
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The UCHT1 antibody reacts with the ~20 kDa CD3\u03b5 subunit of the human T cell receptor (TCR)\/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NKT cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex, which is assembled from combinations of CD3\u03b3, \u03b4, \u03b5, \u03b7, and \u03b6 subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders including severe combined immunodeficiency (SCID).<\/p>\n

This antibody clone has been verified for purity assessments of cells isolated with EasySep\u2122 kits, including EasySep\u2122 Direct Human T Cell Isolation Kit, EasySep\u2122 Human CD3 Positive Selection Kit II (Catalog #17851; partial blocking may be observed), EasySep\u2122 HLA Whole Blood T Cell Enrichment Kit\u00a0 and EasySep\u2122 HLA Whole Blood CD2 Positive Selection Kit.<\/p><\/div>\n<\/div>\n<\/div>\n

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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD3<\/div>\n<\/div>\n
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Alternative Names: CD3e, CD3epsilon, T3<\/div>\n<\/div>\n
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Reactive Species: Chimpanzee; Human<\/div>\n<\/div>\n
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Conjugation: APC; FITC; PE<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: T Cells<\/div>\n<\/div>\n
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Application: CyTOF; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Western Blotting<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: UCHT1<\/div>\n<\/div>\n
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Gene ID: 915<\/div>\n<\/div>\n
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Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The UCHT1 antibody reacts with the ~20 kDa CD3\u03b5 subunit of the human T cell receptor (TCR)\/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NKT cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex, which is assembled from combinations of CD3\u03b3, \u03b4, \u03b5, \u03b7, and \u03b6 subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders including severe combined immunodeficiency (SCID). This antibody clone has been verified for purity assessments of cells isolated with EasySep\u2122 kits, including EasySep\u2122 Direct Human T Cell Isolation Kit, EasySep\u2122 Human CD3 Positive Selection Kit II (Catalog #17851; partial blocking may be observed), EasySep\u2122 HLA Whole Blood T Cell Enrichment Kit\u00a0 and EasySep\u2122 HLA Whole Blood CD2 Positive Selection Kit. Subtype: Primary Antibodies Target Antigen: CD3 Alternative Names: CD3e, CD3epsilon, T3 Reactive Species: Chimpanzee; Human Conjugation: APC; FITC; PE Host Species: Mouse Cell Type: T Cells Application: CyTOF; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Western Blotting Area of Interest: Immunology Clone: UCHT1 Gene ID: 915 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2567,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2634","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2567"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2634"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2634"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2634"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}