{"id":2647,"date":"2020-11-18T13:36:24","date_gmt":"2020-11-18T13:36:24","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2647"},"modified":"2020-11-18T13:36:25","modified_gmt":"2020-11-18T13:36:25","slug":"anti-human-cd38-antibody-clone-at-1-mouse-monoclonal-igg1-antibody-against-human-rhesus-cynomolgus-cd38","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd38-antibody-clone-at-1-mouse-monoclonal-igg1-antibody-against-human-rhesus-cynomolgus-cd38\/","title":{"rendered":"Anti-Human CD38 Antibody, Clone AT-1 Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD38"},"content":{"rendered":"

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Overview<\/h3>\n
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The AT-1 antibody reacts with CD38, an ~45 kDa type II integral membrane glycoprotein that is part of the ADP-ribosyl cyclase family. CD38 is widely expressed at variable levels on hematopoietic cells including early B and T cell lineages, activated B and T cells, NK cells, monocytes, and dendritic cells. It is strongly expressed in plasma cells. CD38 is also expressed in some non-hematopoietic tissues such as brain, kidney, muscle, and pancreas. CD38 is an ectoenzyme that acts as both an ADP-ribosyl cyclase and ADP-ribose (ADPR) hydrolase for the synthesis and hydrolysis of cyclic ADPR (cADPR) and NAADP. cADPR acts as a second messenger for intracellular calcium mobilization to facilitate glucose-induced insulin secretion. It has been shown that the AT-1 antibody mutually competes for binding with OKT10 and SUN-4B7, and all three clones only bind the native (not reduced) form of CD38.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD38<\/div>\n<\/div>\n
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Alternative Names: ADP-ribosyl cyclase, cADPR, Cyclic ADP-ribose hydrolase, T10<\/div>\n<\/div>\n
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Reactive Species: Human; Cynomolgus; Rhesus<\/div>\n<\/div>\n
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Conjugation: FITC<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: B Cells; Plasma Cells; Hematopoietic Stem and Progenitor Cells<\/div>\n<\/div>\n
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Application: Cell Isolation; Flow Cytometry<\/div>\n<\/div>\n
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Area of Interest: Immunology; Stem Cell Biology<\/div>\n<\/div>\n
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Clone: AT-1<\/div>\n<\/div>\n
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Gene ID: 952<\/div>\n<\/div>\n
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Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The AT-1 antibody reacts with CD38, an ~45 kDa type II integral membrane glycoprotein that is part of the ADP-ribosyl cyclase family. CD38 is widely expressed at variable levels on hematopoietic cells including early B and T cell lineages, activated B and T cells, NK cells, monocytes, and dendritic cells. It is strongly expressed in plasma cells. CD38 is also expressed in some non-hematopoietic tissues such as brain, kidney, muscle, and pancreas. CD38 is an ectoenzyme that acts as both an ADP-ribosyl cyclase and ADP-ribose (ADPR) hydrolase for the synthesis and hydrolysis of cyclic ADPR (cADPR) and NAADP. cADPR acts as a second messenger for intracellular calcium mobilization to facilitate glucose-induced insulin secretion. It has been shown that the AT-1 antibody mutually competes for binding with OKT10 and SUN-4B7, and all three clones only bind the native (not reduced) form of CD38. Subtype: Primary Antibodies Target Antigen: CD38 Alternative Names: ADP-ribosyl cyclase, cADPR, Cyclic ADP-ribose hydrolase, T10 Reactive Species: Human; Cynomolgus; Rhesus Conjugation: FITC Host Species: Mouse Cell Type: B Cells; Plasma Cells; Hematopoietic Stem and Progenitor Cells Application: Cell Isolation; Flow Cytometry Area of Interest: Immunology; Stem Cell Biology Clone: AT-1 Gene ID: 952 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2572,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2647","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2647","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2572"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2647"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2647"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2647"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}