{"id":2650,"date":"2020-11-18T14:10:05","date_gmt":"2020-11-18T14:10:05","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2650"},"modified":"2020-11-18T14:10:06","modified_gmt":"2020-11-18T14:10:06","slug":"anti-human-cd4-antibody-clone-sk3-mouse-monoclonal-igg1-antibody-against-human-rhesus-cynomolgus-cd4","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd4-antibody-clone-sk3-mouse-monoclonal-igg1-antibody-against-human-rhesus-cynomolgus-cd4\/","title":{"rendered":"Anti-Human CD4 Antibody, Clone SK3 Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD4"},"content":{"rendered":"

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Overview<\/h3>\n
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The SK3 antibody reacts with CD4, an ~59 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobulin (Ig) superfamily; CD4 contains four extracellular Ig-like domains (D1 – D4). The epitope for SK3 has been localized to the D3 domain of the protein, which has a structure resembling an Ig variable domain. CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T-helper cells), and at lower levels by peripheral blood monocytes and macrophages. CD4 binds to a nonpolymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the affinity of the association between the TCR and MHC II-antigen complex. CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. Moreover, CD4 is a receptor for the human immunodeficiency virus (HIV). Binding of the SK3 antibody blocks HIV binding and mixed lymphocyte reaction (MLR).<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD4; CD5<\/div>\n<\/div>\n
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Reactive Species: Human<\/div>\n<\/div>\n
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Conjugation: PE<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: T Cells, Regulatory; T Cells; T Cells, CD4+<\/div>\n<\/div>\n
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Application: Cell Isolation; Flow Cytometry<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The SK3 antibody reacts with CD4, an ~59 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobulin (Ig) superfamily; CD4 contains four extracellular Ig-like domains (D1 – D4). The epitope for SK3 has been localized to the D3 domain of the protein, which has a structure resembling an Ig variable domain. CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T-helper cells), and at lower levels by peripheral blood monocytes and macrophages. CD4 binds to a nonpolymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the affinity of the association between the TCR and MHC II-antigen complex. CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. Moreover, CD4 is a receptor for the human immunodeficiency virus (HIV). Binding of the SK3 antibody blocks HIV binding and mixed lymphocyte reaction (MLR). Subtype: Primary Antibodies Target Antigen: CD4; CD5 Reactive Species: Human Conjugation: PE Host Species: Mouse Cell Type: T Cells, Regulatory; T Cells; T Cells, CD4+ Application: Cell Isolation; Flow Cytometry Area of Interest: Immunology<\/p>\n","protected":false},"featured_media":2575,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2650","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2650","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2575"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2650"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2650"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2650"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2650"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}