{"id":2651,"date":"2020-11-18T14:12:19","date_gmt":"2020-11-18T14:12:19","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2651"},"modified":"2020-11-18T14:12:19","modified_gmt":"2020-11-18T14:12:19","slug":"anti-human-cd40-antibody-clone-5c3-mouse-monoclonal-igg1-antibody-against-human-rhesus-cynomolgus-cd40","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd40-antibody-clone-5c3-mouse-monoclonal-igg1-antibody-against-human-rhesus-cynomolgus-cd40\/","title":{"rendered":"Anti-Human CD40 Antibody, Clone 5C3 Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD40"},"content":{"rendered":"

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Overview<\/h3>\n
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The 5C3 antibody reacts with CD40, a 45 – 50 kDa type I transmembrane glycoprotein that is a member of the tumor necrosis factor receptor (TNFR) superfamily. CD40 plays an important role in B cell development and is also involved in the process of B cell selection in germinal centers. It facilitates T cell-B cell interactions for co-stimulation and immune regulation through engagement with CD154 (gp39), the CD40 ligand expressed on T cells. In the presence of IL-4, or other stimuli, CD40 promotes B cell proliferation, induces immunoglobulin- (Ig) isotype class switching and rescues B cells from surface Ig-induced apoptosis. CD40 is expressed on the surface of B cells, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, endothelial cells, basal epithelial cells, CD34+ hematopoietic progenitor cells, and primary carcinomas. It is expressed at low levels, or not at all, on plasma cells. The 5C3 antibody has been used for the activation of B cells in in vitro functional assays or for the induction of B cell proliferation.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD40<\/div>\n<\/div>\n
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Alternative Names: B cell surface antigen CD40, Bp50, CD40L receptor, CDw40, HIGM1, IGM, IMD3, Nerve growth factor receptor-related B lymphocyte activation molecule, p50, TBAM, TNFRSF5, TRAP, Tumor necrosis factor receptor superfamily member 5<\/div>\n<\/div>\n
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Reactive Species: Baboon; Cynomolgus; Rhesus; Squirrel Monkey; Chimpanzee; Human<\/div>\n<\/div>\n
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Conjugation: Alexa Fluor 488; APC; FITC; PE; Unconjugated<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: B Cells<\/div>\n<\/div>\n
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Application: Flow Cytometry; Functional Assay; Immunohistochemistry<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: 5C3<\/div>\n<\/div>\n
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Gene ID: 958<\/div>\n<\/div>\n
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Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The 5C3 antibody reacts with CD40, a 45 – 50 kDa type I transmembrane glycoprotein that is a member of the tumor necrosis factor receptor (TNFR) superfamily. CD40 plays an important role in B cell development and is also involved in the process of B cell selection in germinal centers. It facilitates T cell-B cell interactions for co-stimulation and immune regulation through engagement with CD154 (gp39), the CD40 ligand expressed on T cells. In the presence of IL-4, or other stimuli, CD40 promotes B cell proliferation, induces immunoglobulin- (Ig) isotype class switching and rescues B cells from surface Ig-induced apoptosis. CD40 is expressed on the surface of B cells, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, endothelial cells, basal epithelial cells, CD34+ hematopoietic progenitor cells, and primary carcinomas. It is expressed at low levels, or not at all, on plasma cells. The 5C3 antibody has been used for the activation of B cells in in vitro functional assays or for the induction of B cell proliferation. Subtype: Primary Antibodies Target Antigen: CD40 Alternative Names: B cell surface antigen CD40, Bp50, CD40L receptor, CDw40, HIGM1, IGM, IMD3, Nerve growth factor receptor-related B lymphocyte activation molecule, p50, TBAM, TNFRSF5, TRAP, Tumor necrosis factor receptor superfamily member 5 Reactive Species: Baboon; Cynomolgus; Rhesus; Squirrel Monkey; Chimpanzee; Human Conjugation: Alexa Fluor 488; APC; FITC; PE; Unconjugated Host Species: Mouse Cell Type: B Cells Application: Flow Cytometry; Functional Assay; Immunohistochemistry Area of Interest: Immunology Clone: 5C3 Gene ID: 958 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2651","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2651","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2651"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2651"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2651"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}