{"id":2652,"date":"2020-11-18T14:14:22","date_gmt":"2020-11-18T14:14:22","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2652"},"modified":"2020-11-18T14:14:22","modified_gmt":"2020-11-18T14:14:22","slug":"anti-human-cd41-antibody-clone-hip8-mouse-monoclonal-igg1-antibody-against-human-rhesus-cynomolgus-cd41","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd41-antibody-clone-hip8-mouse-monoclonal-igg1-antibody-against-human-rhesus-cynomolgus-cd41\/","title":{"rendered":"Anti-Human CD41 Antibody, Clone HIP8 Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD41"},"content":{"rendered":"

\"\" \"\"<\/p>\n

Overview<\/h3>\n
\n
\n
The HIP8 antibody reacts with the ~125 kDa GPIIb\u03b1 subunit of human CD41, a heterodimeric integrin expressed primarily on platelets, megakaryocytes, monocytes, and acute megakaryoblastic leukemia cells. The GPIIb\u03b1 subunit is linked to a smaller ~25 kDa subunit (GPIIb\u03b2) by a single disulfide bond. Three isoforms of CD41 that are generated by alternative splicing have been identified, one of which is expressed only by cancerous cells. CD41 associates non-covalently with CD61 (integrin b3) in a calcium-dependent manner to form the CD41\/CD61 (or GPIIb\/IIIa) complex, which has been identified as a receptor for several ligands, including fibrinogen, fibronectin, vitronectin, and thrombin. Binding to the CD41\/CD61 complex involves an RGD tripeptidyl sequence in the ligand, and both ligand occupancy and ligand-mediated receptor clustering are functionally important in the integrin-mediated response. The HIP8 antibody reportedly blocks platelet aggregation and inhibits the activation of platelets by several compounds.<\/div>\n<\/div>\n<\/div>\n
<\/div>\n
<\/div>\n
\n
\n
\n
\n
\n
Subtype: Primary Antibodies<\/div>\n<\/div>\n
\n
Target Antigen: CD41<\/div>\n<\/div>\n
\n
Alternative Names: GPIIb, Integrin alpha 2b, Integrin alpha llb, ITGA2B, Platelet glycoprotein IIb<\/div>\n<\/div>\n
\n
Reactive Species: Human; Rhesus; Cynomolgus; Pig; Baboon; Capuchin Monkey; Chimpanzee<\/div>\n<\/div>\n
\n
Conjugation: APC; FITC; PE; Unconjugated<\/div>\n<\/div>\n
\n
Host Species: Mouse<\/div>\n<\/div>\n
\n
Cell Type: Megakaryocytes; Platelets<\/div>\n<\/div>\n
\n
Application: CyTOF; Functional Assay; Flow Cytometry; Immunofluorescence; Immunohistochemistry; Neutralization and Blocking<\/div>\n<\/div>\n
\n
Area of Interest: Immunology<\/div>\n<\/div>\n
\n
Clone: HIP8<\/div>\n<\/div>\n
\n
Gene ID: 3674<\/div>\n<\/div>\n
\n
Isotype: IgG1, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The HIP8 antibody reacts with the ~125 kDa GPIIb\u03b1 subunit of human CD41, a heterodimeric integrin expressed primarily on platelets, megakaryocytes, monocytes, and acute megakaryoblastic leukemia cells. The GPIIb\u03b1 subunit is linked to a smaller ~25 kDa subunit (GPIIb\u03b2) by a single disulfide bond. Three isoforms of CD41 that are generated by alternative splicing have been identified, one of which is expressed only by cancerous cells. CD41 associates non-covalently with CD61 (integrin b3) in a calcium-dependent manner to form the CD41\/CD61 (or GPIIb\/IIIa) complex, which has been identified as a receptor for several ligands, including fibrinogen, fibronectin, vitronectin, and thrombin. Binding to the CD41\/CD61 complex involves an RGD tripeptidyl sequence in the ligand, and both ligand occupancy and ligand-mediated receptor clustering are functionally important in the integrin-mediated response. The HIP8 antibody reportedly blocks platelet aggregation and inhibits the activation of platelets by several compounds. Subtype: Primary Antibodies Target Antigen: CD41 Alternative Names: GPIIb, Integrin alpha 2b, Integrin alpha llb, ITGA2B, Platelet glycoprotein IIb Reactive Species: Human; Rhesus; Cynomolgus; Pig; Baboon; Capuchin Monkey; Chimpanzee Conjugation: APC; FITC; PE; Unconjugated Host Species: Mouse Cell Type: Megakaryocytes; Platelets Application: CyTOF; Functional Assay; Flow Cytometry; Immunofluorescence; Immunohistochemistry; Neutralization and Blocking Area of Interest: Immunology Clone: HIP8 Gene ID: 3674 Isotype: IgG1, kappa<\/p>\n","protected":false},"featured_media":2572,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2652","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2572"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2652"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2652"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2652"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}