{"id":2657,"date":"2020-11-19T09:02:46","date_gmt":"2020-11-19T09:02:46","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2657"},"modified":"2020-11-19T09:02:46","modified_gmt":"2020-11-19T09:02:46","slug":"anti-human-cd51-antibody-clone-nki-m9-mouse-monoclonal-igg2a-antibody-against-human-cd51-integrin-%ce%b1v","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd51-antibody-clone-nki-m9-mouse-monoclonal-igg2a-antibody-against-human-cd51-integrin-%ce%b1v\/","title":{"rendered":"Anti-Human CD51 Antibody, Clone NKI-M9 Mouse monoclonal IgG2a antibody against human CD51 (integrin \u03b1V)"},"content":{"rendered":"

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Overview<\/h3>\n
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The NKI-M9 antibody reacts with CD51 (vitronectin receptor \u03b1 chain, or integrin \u03b1V), a type I transmembrane glycoprotein containing two subunits (125 kDa and 24 kDa) which are generated by post-translational cleavage and are linked by a disulfide bond. CD51 associates non-covalently with integrin \u03b21 (CD29), \u03b23 (CD61), \u03b25, \u03b26, or \u03b28 to form heterodimeric cell adhesion receptors for extracellular matrix components such as fibrinogen, collagen, fibronectin, laminin, osteopontin, thrombospondin, vitronectin, and von Willebrand factor. For example, association of CD51 and CD61 forms the integrin \u03b1v\/\u03b23 receptor primarily involved in binding vitronectin. In addition to mediating adhesion and cytoskeletal organization, CD51-containing integrins have roles in signal transduction and thereby modulate processes such as cell proliferation, differentiation, and migration. Both ligand binding and ligand-induced receptor clustering are necessary for initiating integrin-mediated responses. CD51 is expressed broadly on many types of cells, including endothelial cells, fibroblasts, monocytes, macrophages, platelets (at relatively low levels), and osteoclasts. It is also found on hepatoma, melanoma, and neuroblastoma cells.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD51 (Integrin \u03b1V)<\/div>\n<\/div>\n
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Alternative Names: \u03b1V integrin, integrin \u03b1V, vitronectin receptor \u03b1 chain<\/div>\n<\/div>\n
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Reactive Species: Human<\/div>\n<\/div>\n
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Conjugation: Biotin; FITC; PE; Unconjugated<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: Mesenchymal Stem and Progenitor Cells<\/div>\n<\/div>\n
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Application: ELISA; Flow Cytometry; Functional Assay; Immunoprecipitation<\/div>\n<\/div>\n
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Area of Interest: Stem Cell Biology<\/div>\n<\/div>\n
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Clone: NKI-M9<\/div>\n<\/div>\n
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Gene ID: 3685<\/div>\n<\/div>\n
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Isotype: IgG2a, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The NKI-M9 antibody reacts with CD51 (vitronectin receptor \u03b1 chain, or integrin \u03b1V), a type I transmembrane glycoprotein containing two subunits (125 kDa and 24 kDa) which are generated by post-translational cleavage and are linked by a disulfide bond. CD51 associates non-covalently with integrin \u03b21 (CD29), \u03b23 (CD61), \u03b25, \u03b26, or \u03b28 to form heterodimeric cell adhesion receptors for extracellular matrix components such as fibrinogen, collagen, fibronectin, laminin, osteopontin, thrombospondin, vitronectin, and von Willebrand factor. For example, association of CD51 and CD61 forms the integrin \u03b1v\/\u03b23 receptor primarily involved in binding vitronectin. In addition to mediating adhesion and cytoskeletal organization, CD51-containing integrins have roles in signal transduction and thereby modulate processes such as cell proliferation, differentiation, and migration. Both ligand binding and ligand-induced receptor clustering are necessary for initiating integrin-mediated responses. CD51 is expressed broadly on many types of cells, including endothelial cells, fibroblasts, monocytes, macrophages, platelets (at relatively low levels), and osteoclasts. It is also found on hepatoma, melanoma, and neuroblastoma cells. Subtype: Primary Antibodies Target Antigen: CD51 (Integrin \u03b1V) Alternative Names: \u03b1V integrin, integrin \u03b1V, vitronectin receptor \u03b1 chain Reactive Species: Human Conjugation: Biotin; FITC; PE; Unconjugated Host Species: Mouse Cell Type: Mesenchymal Stem and Progenitor Cells Application: ELISA; Flow Cytometry; Functional Assay; Immunoprecipitation Area of Interest: Stem Cell Biology Clone: NKI-M9 Gene ID: 3685 Isotype: IgG2a, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2657","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2657","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2657"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2657"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2657"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}