{"id":2661,"date":"2020-11-19T09:17:41","date_gmt":"2020-11-19T09:17:41","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2661"},"modified":"2020-11-19T09:17:42","modified_gmt":"2020-11-19T09:17:42","slug":"anti-human-cd68-antibody-clone-y1-82a-mouse-monoclonal-igg2b-antibody-against-human-cd68","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-cd68-antibody-clone-y1-82a-mouse-monoclonal-igg2b-antibody-against-human-cd68\/","title":{"rendered":"Anti-Human CD68 Antibody, Clone Y1\/82A Mouse monoclonal IgG2b antibody against human CD68"},"content":{"rendered":"

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Overview<\/h3>\n
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The Y1\/82A antibody reacts with human CD68, an ~110 kDa type 1 transmembrane glycoprotein and member of the sialomucin, LAMP and scavenger receptor families. The heavily glycosylated extracellular domain of CD68, which contains a praline-rich spacer region separating mucin and LAMP domains, binds low-density lipoprotein and certain lectins and selectins, though the function of CD68 remains unclear. CD68 is highly expressed in lysosomes, endosomes and cytoplasmic granules, and more weakly on the surface of macrophages, monocytes, neutrophils, basophils, dendritic cells and NK cells. It has also been detected in the cytoplasm of \u03b3\/\u03b4 T cells, LAK cells, fibroblasts, endothelial cells and subsets of B cells and hematopoietic progenitors, as well as in various non-hematopoietic tissues such as liver and kidney. The Y1\/82A antibody recognizes an epitope distinct from those of antibody clones Y2\/131, EBM11, Ki-M6 and KP1. Y1\/82A is reportedly more specific for monocytes and macrophages than KP1.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD68<\/div>\n<\/div>\n
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Alternative Names: GP110, LAMP4, Lysosomal-associated membrane protein, Macrosialin, SCARD1, Scavenger receptor class D member 1<\/div>\n<\/div>\n
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Reactive Species: Human<\/div>\n<\/div>\n
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Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; Unconjugated<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: Granulocytes and Subsets; Myeloid Cells<\/div>\n<\/div>\n
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Application: Flow Cytometry; Immunofluorescence; Immunocytochemistry; Immunohistochemistry; Immunoprecipitation; Western Blotting<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: Y1\/82A<\/div>\n<\/div>\n
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Gene ID: 968<\/div>\n<\/div>\n
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Isotype: IgG2b, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The Y1\/82A antibody reacts with human CD68, an ~110 kDa type 1 transmembrane glycoprotein and member of the sialomucin, LAMP and scavenger receptor families. The heavily glycosylated extracellular domain of CD68, which contains a praline-rich spacer region separating mucin and LAMP domains, binds low-density lipoprotein and certain lectins and selectins, though the function of CD68 remains unclear. CD68 is highly expressed in lysosomes, endosomes and cytoplasmic granules, and more weakly on the surface of macrophages, monocytes, neutrophils, basophils, dendritic cells and NK cells. It has also been detected in the cytoplasm of \u03b3\/\u03b4 T cells, LAK cells, fibroblasts, endothelial cells and subsets of B cells and hematopoietic progenitors, as well as in various non-hematopoietic tissues such as liver and kidney. The Y1\/82A antibody recognizes an epitope distinct from those of antibody clones Y2\/131, EBM11, Ki-M6 and KP1. Y1\/82A is reportedly more specific for monocytes and macrophages than KP1. Subtype: Primary Antibodies Target Antigen: CD68 Alternative Names: GP110, LAMP4, Lysosomal-associated membrane protein, Macrosialin, SCARD1, Scavenger receptor class D member 1 Reactive Species: Human Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; Unconjugated Host Species: Mouse Cell Type: Granulocytes and Subsets; Myeloid Cells Application: Flow Cytometry; Immunofluorescence; Immunocytochemistry; Immunohistochemistry; Immunoprecipitation; Western Blotting Area of Interest: Immunology Clone: Y1\/82A Gene ID: 968 Isotype: IgG2b, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2661","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2661"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2661"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2661"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}