{"id":2672,"date":"2020-11-19T10:16:23","date_gmt":"2020-11-19T10:16:23","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2672"},"modified":"2020-11-19T10:16:23","modified_gmt":"2020-11-19T10:16:23","slug":"anti-human-muc1-cd227-antibody-clone-214d4-mouse-monoclonal-igg1-antibody-against-human-muc1-cd227","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-muc1-cd227-antibody-clone-214d4-mouse-monoclonal-igg1-antibody-against-human-muc1-cd227\/","title":{"rendered":"Anti-Human MUC1 (CD227) Antibody, Clone 214D4 Mouse monoclonal IgG1 antibody against human MUC1 (CD227)"},"content":{"rendered":"

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Overview<\/h3>\n
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The 214D4 antibody reacts with MUC1 (also known as CD227), a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells as well as a variety of hematopoietic cells. A characteristic feature of the MUC1 (CD227) glycoprotein is a core protein domain composed of a variable number of tandem repeats and multiple oligosaccharide side chains. Because the extracellular portion of MUC1 can extend beyond most cell surface proteins, it is thought to play a role in cell-cell and cell-substrate adhesion. The protein is highly expressed by the majority of human adenocarcinomas and is associated with a poor prognosis. In the mammary gland, MUC1 is localized on the apical plasma membrane of luminal epithelial cells. The 214D4 antibody clone is particularly useful since it enriches for luminal-restricted but not bipotent epithelial progenitor cells from normal human mammary tissue.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: MUC1 (CD227)<\/div>\n<\/div>\n
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Alternative Names: CD227, EMA, Episialin, Epithelial membrane antigen, HMFG antigen, MAM6, Mucin 1, PEM, Polymorphic epithelial mucin<\/div>\n<\/div>\n
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Reactive Species: Human<\/div>\n<\/div>\n
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Conjugation: Unconjugated<\/div>\n<\/div>\n
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Host Species: Mouse<\/div>\n<\/div>\n
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Cell Type: Mammary Cells<\/div>\n<\/div>\n
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Application: Cell Isolation; Immunohistochemistry<\/div>\n<\/div>\n
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Area of Interest: Stem Cell Biology; Epithelial Cell Biology<\/div>\n<\/div>\n
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Clone: 214D4<\/div>\n<\/div>\n
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Gene ID: 4582<\/div>\n<\/div>\n
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Isotype: IgG1<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The 214D4 antibody reacts with MUC1 (also known as CD227), a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells as well as a variety of hematopoietic cells. A characteristic feature of the MUC1 (CD227) glycoprotein is a core protein domain composed of a variable number of tandem repeats and multiple oligosaccharide side chains. Because the extracellular portion of MUC1 can extend beyond most cell surface proteins, it is thought to play a role in cell-cell and cell-substrate adhesion. The protein is highly expressed by the majority of human adenocarcinomas and is associated with a poor prognosis. In the mammary gland, MUC1 is localized on the apical plasma membrane of luminal epithelial cells. The 214D4 antibody clone is particularly useful since it enriches for luminal-restricted but not bipotent epithelial progenitor cells from normal human mammary tissue. Subtype: Primary Antibodies Target Antigen: MUC1 (CD227) Alternative Names: CD227, EMA, Episialin, Epithelial membrane antigen, HMFG antigen, MAM6, Mucin 1, PEM, Polymorphic epithelial mucin Reactive Species: Human Conjugation: Unconjugated Host Species: Mouse Cell Type: Mammary Cells Application: Cell Isolation; Immunohistochemistry Area of Interest: Stem Cell Biology; Epithelial Cell Biology Clone: 214D4 Gene ID: 4582 Isotype: IgG1<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2672","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2672","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2672"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2672"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2672"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2672"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}