{"id":2675,"date":"2020-11-19T10:30:32","date_gmt":"2020-11-19T10:30:32","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2675"},"modified":"2020-11-19T10:30:33","modified_gmt":"2020-11-19T10:30:33","slug":"anti-human-p63-deltan-antibody-clone-poly6190-rabbit-polyclonal-antibody-against-human-p63-deltan","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-human-p63-deltan-antibody-clone-poly6190-rabbit-polyclonal-antibody-against-human-p63-deltan\/","title":{"rendered":"Anti-Human p63 (deltaN) Antibody, Clone Poly6190 Rabbit polyclonal antibody against human p63 (deltaN)"},"content":{"rendered":"

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Overview<\/h3>\n
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The Poly6190 antibody reacts with the deltaN isoforms of human p63, a member of the p53 family of transcription factors. Alternative splicing of the p63 transcript gives rise to two classes of isoforms. The TA isoforms (TA p63-\u03b1, -\u03b2, -\u03b3) possess an N-terminal transactivation domain, while the deltaN isoforms (deltaN p63-\u03b1, -\u03b2, -\u03b3) lack the transactivation domain. The TA isoforms are capable of transactivating p53 targets, whereas they antagonize p53. The deltaN isoforms are generally dominant to the TA isoforms and repress the latter. The p63 protein is localized to the nucleus and plays an important role in epithelial stem cell regeneration, epidermal morphogenesis, limb development, and stratification.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: p63 (deltaN)<\/div>\n<\/div>\n
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Alternative Names: TP63, Tumor protein P63<\/div>\n<\/div>\n
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Reactive Species: Human<\/div>\n<\/div>\n
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Conjugation: Unconjugated<\/div>\n<\/div>\n
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Host Species: Rabbit<\/div>\n<\/div>\n
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Cell Type: Airway Cells; Dermal Cells<\/div>\n<\/div>\n
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Application: Immunohistochemistry; Immunocytochemistry; Immunofluorescence; Western Blotting<\/div>\n<\/div>\n
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Area of Interest: Stem Cell Biology; Epithelial Cell Biology<\/div>\n<\/div>\n
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Clone: Not applicable (poly6190)<\/div>\n<\/div>\n
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Gene ID: 8626<\/div>\n<\/div>\n
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Isotype: IgG<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The Poly6190 antibody reacts with the deltaN isoforms of human p63, a member of the p53 family of transcription factors. Alternative splicing of the p63 transcript gives rise to two classes of isoforms. The TA isoforms (TA p63-\u03b1, -\u03b2, -\u03b3) possess an N-terminal transactivation domain, while the deltaN isoforms (deltaN p63-\u03b1, -\u03b2, -\u03b3) lack the transactivation domain. The TA isoforms are capable of transactivating p53 targets, whereas they antagonize p53. The deltaN isoforms are generally dominant to the TA isoforms and repress the latter. The p63 protein is localized to the nucleus and plays an important role in epithelial stem cell regeneration, epidermal morphogenesis, limb development, and stratification. Subtype: Primary Antibodies Target Antigen: p63 (deltaN) Alternative Names: TP63, Tumor protein P63 Reactive Species: Human Conjugation: Unconjugated Host Species: Rabbit Cell Type: Airway Cells; Dermal Cells Application: Immunohistochemistry; Immunocytochemistry; Immunofluorescence; Western Blotting Area of Interest: Stem Cell Biology; Epithelial Cell Biology Clone: Not applicable (poly6190) Gene ID: 8626 Isotype: IgG<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2675","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2675","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2675"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2675"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2675"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}