{"id":2731,"date":"2020-11-30T09:54:41","date_gmt":"2020-11-30T09:54:41","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2731"},"modified":"2020-11-30T09:54:41","modified_gmt":"2020-11-30T09:54:41","slug":"anti-mouse-cd150-antibody-clone-tc15-12f12-2-rat-monoclonal-igg2a-antibody-against-mouse-cd150-slam","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-cd150-antibody-clone-tc15-12f12-2-rat-monoclonal-igg2a-antibody-against-mouse-cd150-slam\/","title":{"rendered":"Anti-Mouse CD150 Antibody, Clone TC15-12F12.2 Rat monoclonal IgG2a antibody against mouse CD150 (SLAM)"},"content":{"rendered":"

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Overview<\/h3>\n
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The TC15-12F12.2 antibody reacts with CD150 (signaling lymphocyte activation molecule or SLAM), an ~75 kDa type I transmembrane glycoprotein that plays multiple roles in the immune response by serving as a cell adhesion molecule and\/or coreceptor. It is differentially expressed by T cells, immature thymocytes, B cells, dendritic cells, macrophages, and endothelial cells. The expression pattern differs according to cell type and activation status. Expression is rapidly induced upon activation of T cells, B cells and dendritic cells, with synthesis by T cells being maintained on Th1 but not Th2 clones. CD150-mediated co-stimulation of TCR-activated T cells enhances the production of IFN-\u03b3 by Th1 cells, a response that can be augmented by binding of the TC15-12F12.2 antibody. CD150 is thought to mediate signal transduction by associating with the intracellular protein tyrosine phosphatase, SHP-2. CD150 also has functions in hematopoietic cell development and is a useful marker for detection of multipotent hematopoietic stem cells (in concert with other markers such as CD48 and CD41). CD150 is not expressed on non-multipotent hematopoietic progenitor cells.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD150 (SLAM)<\/div>\n<\/div>\n
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Alternative Names: IPO-3, Signaling lymphocyte activation molecule<\/div>\n<\/div>\n
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Reactive Species: Mouse<\/div>\n<\/div>\n
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Conjugation: Alexa Fluor 488; APC; Biotin; PE; Unconjugated; PE-Cyanine7<\/div>\n<\/div>\n
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Host Species: Rat; Hamster<\/div>\n<\/div>\n
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Cell Type: Hematopoietic Stem and Progenitor Cells<\/div>\n<\/div>\n
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Application: Flow Cytometry; Functional Assay; Immunofluorescence; Immunohistochemistry; Immunoprecipitation<\/div>\n<\/div>\n
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Area of Interest: Stem Cell Biology<\/div>\n<\/div>\n
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Clone: TC15-12F12.2<\/div>\n<\/div>\n
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Gene ID: 27218<\/div>\n<\/div>\n
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Isotype: IgG2a, lambda<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The TC15-12F12.2 antibody reacts with CD150 (signaling lymphocyte activation molecule or SLAM), an ~75 kDa type I transmembrane glycoprotein that plays multiple roles in the immune response by serving as a cell adhesion molecule and\/or coreceptor. It is differentially expressed by T cells, immature thymocytes, B cells, dendritic cells, macrophages, and endothelial cells. The expression pattern differs according to cell type and activation status. Expression is rapidly induced upon activation of T cells, B cells and dendritic cells, with synthesis by T cells being maintained on Th1 but not Th2 clones. CD150-mediated co-stimulation of TCR-activated T cells enhances the production of IFN-\u03b3 by Th1 cells, a response that can be augmented by binding of the TC15-12F12.2 antibody. CD150 is thought to mediate signal transduction by associating with the intracellular protein tyrosine phosphatase, SHP-2. CD150 also has functions in hematopoietic cell development and is a useful marker for detection of multipotent hematopoietic stem cells (in concert with other markers such as CD48 and CD41). CD150 is not expressed on non-multipotent hematopoietic progenitor cells. Subtype: Primary Antibodies Target Antigen: CD150 (SLAM) Alternative Names: IPO-3, Signaling lymphocyte activation molecule Reactive Species: Mouse Conjugation: Alexa Fluor 488; APC; Biotin; PE; Unconjugated; PE-Cyanine7 Host Species: Rat; Hamster Cell Type: Hematopoietic Stem and Progenitor Cells Application: Flow Cytometry; Functional Assay; Immunofluorescence; Immunohistochemistry; Immunoprecipitation Area of Interest: Stem Cell Biology Clone: TC15-12F12.2 Gene ID: 27218 Isotype: IgG2a, lambda<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2731","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2731"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2731"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2731"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}