{"id":2733,"date":"2020-12-05T11:21:49","date_gmt":"2020-12-05T11:21:49","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2733"},"modified":"2020-12-05T11:21:49","modified_gmt":"2020-12-05T11:21:49","slug":"anti-mouse-cd19-antibody-clone-1d3-rat-monoclonal-igg2a-antibody-against-mouse-cd19","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-cd19-antibody-clone-1d3-rat-monoclonal-igg2a-antibody-against-mouse-cd19\/","title":{"rendered":"Anti-Mouse CD19 Antibody, Clone 1D3 Rat monoclonal IgG2a antibody against mouse CD19"},"content":{"rendered":"

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Overview<\/h3>\n
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The 1D3 antibody reacts with mouse CD19, an ~95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells. Expression is down-regulated but persists in terminally differentiated plasma cells. CD19 is also found on follicular dendritic cells. By associating with CD21 and CD81, CD19 functions as a co-receptor for the B cell receptor and is involved in B cell activation and differentiation. Activation of CD19 is accompanied by phosphorylation of the cytoplasmic domain, which promotes binding to kinases and the induction of intracellular signaling cascades. Mutations in CD19 can result in severe immunodeficiency syndromes. Clone 1D3 recognizes the same epitope as clone 6D5 in cross-competition assays.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD19<\/div>\n<\/div>\n
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Alternative Names:<\/div>\n
B4<\/div>\n<\/div>\n
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Reactive Species:<\/div>\n
Mouse<\/div>\n<\/div>\n
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Conjugation:<\/div>\n
APC; Biotin; FITC; PE; PerCP-Cyanine5.5; Unconjugated<\/div>\n<\/div>\n
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Host Species:<\/div>\n
Rat<\/div>\n<\/div>\n
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Cell Type:<\/div>\n
B Cells<\/div>\n<\/div>\n
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Application:<\/div>\n
Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation<\/div>\n<\/div>\n
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Area of Interest:<\/div>\n
Immunology<\/div>\n<\/div>\n
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Clone:<\/div>\n
1D3<\/div>\n<\/div>\n
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Gene ID:<\/div>\n
12478<\/div>\n<\/div>\n
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Isotype:<\/div>\n
IgG2a, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The 1D3 antibody reacts with mouse CD19, an ~95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells. Expression is down-regulated but persists in terminally differentiated plasma cells. CD19 is also found on follicular dendritic cells. By associating with CD21 and CD81, CD19 functions as a co-receptor for the B cell receptor and is involved in B cell activation and differentiation. Activation of CD19 is accompanied by phosphorylation of the cytoplasmic domain, which promotes binding to kinases and the induction of intracellular signaling cascades. Mutations in CD19 can result in severe immunodeficiency syndromes. Clone 1D3 recognizes the same epitope as clone 6D5 in cross-competition assays. Subtype: Primary Antibodies Target Antigen: CD19 Alternative Names: B4 Reactive Species: Mouse Conjugation: APC; Biotin; FITC; PE; PerCP-Cyanine5.5; Unconjugated Host Species: Rat Cell Type: B Cells Application: Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation Area of Interest: Immunology Clone: 1D3 Gene ID: 12478 Isotype: IgG2a, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2733","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2733","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2733"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2733"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2733"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}