{"id":2744,"date":"2020-11-30T11:15:25","date_gmt":"2020-11-30T11:15:25","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2744"},"modified":"2020-11-30T11:15:25","modified_gmt":"2020-11-30T11:15:25","slug":"anti-mouse-cd267-taci-antibody-clone-8f10-rat-monoclonal-igg2a-antibody-against-mouse-cd267-taci","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-cd267-taci-antibody-clone-8f10-rat-monoclonal-igg2a-antibody-against-mouse-cd267-taci\/","title":{"rendered":"Anti-Mouse CD267 (TACI) Antibody, Clone 8F10 Rat monoclonal IgG2a antibody against mouse CD267 (TACI)"},"content":{"rendered":"

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Overview<\/h3>\n
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The 8F10 antibody reacts with mouse CD267 (transmembrane activator and CAML interactor, or TACI), an ~30 kDa type III transmembrane protein of the TNF receptor superfamily that is expressed primarily on the surface of maturing subsets of splenic B cells, including transition type 2 (T2) and marginal zone (MZ) B cells, as well as on plasma cells and plasmablasts. Expression of CD267 is upregulated on B cells exposed to LPS both in vitro and in vivo. CD267 plays important roles in humoral immunity by regulating B cell survival, proliferation, and maturation through its interaction with the ligands APRIL and BAFF. Ligand binding stimulates activation of several transcription factors, including NF-kappa-B, and has been shown to induce either proliferation or apoptosis, suggesting a dual role in the regulation of B cells. CD267 also appears to have an essential function in immunoglobulin isotype switching and B cell differentiation in response to thymus-independent antigens.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD267 (TACI)<\/div>\n<\/div>\n
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Reactive Species: Mouse<\/div>\n<\/div>\n
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Conjugation: APC; PE<\/div>\n<\/div>\n
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Host Species: Rat<\/div>\n<\/div>\n
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Cell Type: B Cells<\/div>\n<\/div>\n
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Application: Flow Cytometry<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The 8F10 antibody reacts with mouse CD267 (transmembrane activator and CAML interactor, or TACI), an ~30 kDa type III transmembrane protein of the TNF receptor superfamily that is expressed primarily on the surface of maturing subsets of splenic B cells, including transition type 2 (T2) and marginal zone (MZ) B cells, as well as on plasma cells and plasmablasts. Expression of CD267 is upregulated on B cells exposed to LPS both in vitro and in vivo. CD267 plays important roles in humoral immunity by regulating B cell survival, proliferation, and maturation through its interaction with the ligands APRIL and BAFF. Ligand binding stimulates activation of several transcription factors, including NF-kappa-B, and has been shown to induce either proliferation or apoptosis, suggesting a dual role in the regulation of B cells. CD267 also appears to have an essential function in immunoglobulin isotype switching and B cell differentiation in response to thymus-independent antigens. Subtype: Primary Antibodies Target Antigen: CD267 (TACI) Reactive Species: Mouse Conjugation: APC; PE Host Species: Rat Cell Type: B Cells Application: Flow Cytometry Area of Interest: Immunology<\/p>\n","protected":false},"featured_media":2575,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2744","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2575"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2744"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2744"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2744"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}