{"id":2754,"date":"2020-11-30T11:56:45","date_gmt":"2020-11-30T11:56:45","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2754"},"modified":"2020-11-30T11:56:45","modified_gmt":"2020-11-30T11:56:45","slug":"anti-mouse-cd48-slamf2-antibody-clone-hm48-1-hamster-armenian-monoclonal-igg1-antibody-against-mouse-cd48-slamf2","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-cd48-slamf2-antibody-clone-hm48-1-hamster-armenian-monoclonal-igg1-antibody-against-mouse-cd48-slamf2\/","title":{"rendered":"Anti-Mouse CD48 (SLAMF2) Antibody, Clone HM48-1 Hamster (Armenian) monoclonal IgG1 antibody against mouse CD48 (SLAMF2)"},"content":{"rendered":"

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Overview<\/h3>\n
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The HM48-1 antibody reacts with mouse CD48, a 45 kDa GPI-anchored glycoprotein and a member of the signaling lymphocyte activation molecule (SLAM) family and Ig superfamily. SLAM family members play a role in multiple aspects of immune function including costimulation, cytotoxicity, and cytokine production. CD48 also plays a role in cell adhesion and T cell activation. In mice, CD48 is thought to be present on nearly all hematopoietic cells except neutrophils and ESLAM cells (CD45+EPCR+CD48-CD150+ hematopoietic stem cells with long-term self-renewal capacity). Ligands for CD48 include CD2 and CD244, binding of which helps to promote interactions between immune cells. HM48-1 is reported to be capable of blocking CD48:CD2 and CD48:CD244 interactions in vitro and in vivo. HM48-1 is also reported to inhibit the proliferative response of spleen cells to mitogens, inhibit CTL activity, and enhance the survival of cardiac allografts.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD48 (SLAMF2)<\/div>\n<\/div>\n
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Reactive Species: Mouse<\/div>\n<\/div>\n
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Conjugation: APC<\/div>\n<\/div>\n
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Host Species: Hamster<\/div>\n<\/div>\n
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Cell Type: B Cells; Hematopoietic Stem and Progenitor Cells; Monocytes; T Cells; Macrophages<\/div>\n<\/div>\n
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Application: Flow Cytometry<\/div>\n<\/div>\n
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Area of Interest: Immunology; Stem Cell Biology<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Overview The HM48-1 antibody reacts with mouse CD48, a 45 kDa GPI-anchored glycoprotein and a member of the signaling lymphocyte activation molecule (SLAM) family and Ig superfamily. SLAM family members play a role in multiple aspects of immune function including costimulation, cytotoxicity, and cytokine production. CD48 also plays a role in cell adhesion and T cell activation. In mice, CD48 is thought to be present on nearly all hematopoietic cells except neutrophils and ESLAM cells (CD45+EPCR+CD48-CD150+ hematopoietic stem cells with long-term self-renewal capacity). Ligands for CD48 include CD2 and CD244, binding of which helps to promote interactions between immune cells. HM48-1 is reported to be capable of blocking CD48:CD2 and CD48:CD244 interactions in vitro and in vivo. HM48-1 is also reported to inhibit the proliferative response of spleen cells to mitogens, inhibit CTL activity, and enhance the survival of cardiac allografts. Subtype: Primary Antibodies Target Antigen: CD48 (SLAMF2) Reactive Species: Mouse Conjugation: APC Host Species: Hamster Cell Type: B Cells; Hematopoietic Stem and Progenitor Cells; Monocytes; T Cells; Macrophages Application: Flow Cytometry Area of Interest: Immunology; Stem Cell Biology<\/p>\n","protected":false},"featured_media":2578,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2754","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2578"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2754"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2754"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2754"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}