{"id":2755,"date":"2020-11-30T12:00:37","date_gmt":"2020-11-30T12:00:37","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2755"},"modified":"2020-11-30T12:00:37","modified_gmt":"2020-11-30T12:00:37","slug":"anti-mouse-cd49b-antibody-clone-dx5-rat-monoclonal-igm-antibody-against-mouse-cd49b-integrin-%ce%b12","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-cd49b-antibody-clone-dx5-rat-monoclonal-igm-antibody-against-mouse-cd49b-integrin-%ce%b12\/","title":{"rendered":"Anti-Mouse CD49b Antibody, Clone DX5 Rat monoclonal IgM antibody against mouse CD49b (integrin \u03b12)"},"content":{"rendered":"

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Overview<\/h3>\n
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The DX5 antibody reacts with murine CD49b (integrin \u03b12), an ~150 kDa type 1 transmembrane glycoprotein that associates non-covalently with CD29 (integrin \u03b21) to form the heterodimeric CD49b\/CD29 complex known as VLA-2, a receptor for extracellular matrix proteins such as collagen, E-cadherin, fibronectin, and laminin. CD49b is highly expressed by platelets and is found on a majority of NK cells, on NKT cells, and on a small subset of CD8+ T cells; the latter population increases substantially following viral infection. CD49b is also expressed by several tissues, including intestine, kidney, mammary gland, and lung. The DX5 antibody is particularly useful for identifying NK cells in mice lacking the NK1.1 antigen. Binding of the DX5 antibody has not been observed to affect the function of the VLA-2 integrin. DX5 binding is, however, blocked by the clone HM\u03b12 antibody.<\/p>\n

This antibody clone has been verified for purity assessments of cells isolated with EasySep\u2122 Mouse NK Cell Enrichment Kit.<\/p><\/div>\n<\/div>\n<\/div>\n

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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD49b (Integrin \u03b12)<\/div>\n<\/div>\n
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Alternative Names: \u03b12 integrin, Integrin \u03b12 chain, VLA-2\u03b1 chain<\/div>\n<\/div>\n
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Reactive Species: Mouse<\/div>\n<\/div>\n
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Conjugation: Alexa Fluor 488; Pacific Blue; APC; Biotin; FITC; PE; Unconjugated<\/div>\n<\/div>\n
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Host Species: Rat<\/div>\n<\/div>\n
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Cell Type: NK Cells<\/div>\n<\/div>\n
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Application: Cell Isolation; Flow Cytometry; Immunohistochemistry<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: DX5<\/div>\n<\/div>\n
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Gene ID: 16398<\/div>\n<\/div>\n
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Isotype: IgM, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The DX5 antibody reacts with murine CD49b (integrin \u03b12), an ~150 kDa type 1 transmembrane glycoprotein that associates non-covalently with CD29 (integrin \u03b21) to form the heterodimeric CD49b\/CD29 complex known as VLA-2, a receptor for extracellular matrix proteins such as collagen, E-cadherin, fibronectin, and laminin. CD49b is highly expressed by platelets and is found on a majority of NK cells, on NKT cells, and on a small subset of CD8+ T cells; the latter population increases substantially following viral infection. CD49b is also expressed by several tissues, including intestine, kidney, mammary gland, and lung. The DX5 antibody is particularly useful for identifying NK cells in mice lacking the NK1.1 antigen. Binding of the DX5 antibody has not been observed to affect the function of the VLA-2 integrin. DX5 binding is, however, blocked by the clone HM\u03b12 antibody. This antibody clone has been verified for purity assessments of cells isolated with EasySep\u2122 Mouse NK Cell Enrichment Kit. Subtype: Primary Antibodies Target Antigen: CD49b (Integrin \u03b12) Alternative Names: \u03b12 integrin, Integrin \u03b12 chain, VLA-2\u03b1 chain Reactive Species: Mouse Conjugation: Alexa Fluor 488; Pacific Blue; APC; Biotin; FITC; PE; Unconjugated Host Species: Rat Cell Type: NK Cells Application: Cell Isolation; Flow Cytometry; Immunohistochemistry Area of Interest: Immunology Clone: DX5 Gene ID: 16398 Isotype: IgM, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2755","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2755"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2755"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2755"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}