{"id":2756,"date":"2020-11-30T12:06:09","date_gmt":"2020-11-30T12:06:09","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2756"},"modified":"2020-11-30T12:06:57","modified_gmt":"2020-11-30T12:06:57","slug":"anti-mouse-cd49f-antibody-clone-goh3-rat-monoclonal-igg2a-antibody-against-human-mouse-rhesus-cd49f-integrin-%ce%b16","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-cd49f-antibody-clone-goh3-rat-monoclonal-igg2a-antibody-against-human-mouse-rhesus-cd49f-integrin-%ce%b16\/","title":{"rendered":"Anti-Mouse CD49f Antibody, Clone GoH3 Rat monoclonal IgG2a antibody against human, mouse, rhesus CD49f (integrin \u03b16)"},"content":{"rendered":"

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Overview<\/h3>\n
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The GoH3 antibody reacts with CD49f (integrin \u03b16), an ~150 kDa transmembrane glycoprotein that associates non-covalently with CD29 (integrin \u03b21) or CD104 (integrin \u03b24) to form the heterodimeric receptors VLA-6 and \u03b16\u03b24, which bind the extracellular matrix protein laminin. CD49f is a disulfide-linked dimer comprising an ~120 kDa heavy chain and an ~30 kDa membrane-bound light chain. Splice variants exist, which affect the cytoplasmic domain of the protein. CD49f is expressed on the surface of T cells, monocytes, platelets, placental trophoblasts, epithelial cells, and endothelial cells. It is involved in cell adhesion and regulating signaling pathways involved in a variety of processes, including the activation and proliferation of T cells, and the differentiation and maintenance of stem cell pluripotency. CD49f is considered the most important marker for selecting mouse mammary stem and progenitor cells. The GoH3 antibody reacts with an extracellular epitope on CD49f and reportedly blocks integrin \u03b16 function in vivo and binding of integrin \u03b16 to laminin in vitro.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: CD49f (Integrin \u03b16)<\/div>\n<\/div>\n
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Alternative Names: \u03b16 integrin, integrin \u03b16, VLA-6\u03b1 chain<\/div>\n<\/div>\n
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Reactive Species: Human; Mouse; Rhesus; Cynomolgus; Baboon; Chimpanzee; Capuchin Monkey; Cat; Cow; Dog; Horse; Pig; Rabbit; Sheep<\/div>\n<\/div>\n
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Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; Unconjugated; Pacific Blue<\/div>\n<\/div>\n
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Host Species: Rat<\/div>\n<\/div>\n
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Cell Type: Mammary Cells<\/div>\n<\/div>\n
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Application: Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation<\/div>\n<\/div>\n
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Area of Interest: Immunology; Epithelial Cell Biology<\/div>\n<\/div>\n
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Clone: GoH3<\/div>\n<\/div>\n
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Gene ID: 16403\/3655<\/div>\n<\/div>\n
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Isotype: IgG2a, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The GoH3 antibody reacts with CD49f (integrin \u03b16), an ~150 kDa transmembrane glycoprotein that associates non-covalently with CD29 (integrin \u03b21) or CD104 (integrin \u03b24) to form the heterodimeric receptors VLA-6 and \u03b16\u03b24, which bind the extracellular matrix protein laminin. CD49f is a disulfide-linked dimer comprising an ~120 kDa heavy chain and an ~30 kDa membrane-bound light chain. Splice variants exist, which affect the cytoplasmic domain of the protein. CD49f is expressed on the surface of T cells, monocytes, platelets, placental trophoblasts, epithelial cells, and endothelial cells. It is involved in cell adhesion and regulating signaling pathways involved in a variety of processes, including the activation and proliferation of T cells, and the differentiation and maintenance of stem cell pluripotency. CD49f is considered the most important marker for selecting mouse mammary stem and progenitor cells. The GoH3 antibody reacts with an extracellular epitope on CD49f and reportedly blocks integrin \u03b16 function in vivo and binding of integrin \u03b16 to laminin in vitro. Subtype: Primary Antibodies Target Antigen: CD49f (Integrin \u03b16) Alternative Names: \u03b16 integrin, integrin \u03b16, VLA-6\u03b1 chain Reactive Species: Human; Mouse; Rhesus; Cynomolgus; Baboon; Chimpanzee; Capuchin Monkey; Cat; Cow; Dog; Horse; Pig; Rabbit; Sheep Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; Unconjugated; Pacific Blue Host Species: Rat Cell Type: Mammary Cells Application: Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation Area of Interest: Immunology; Epithelial Cell Biology Clone: GoH3 Gene ID: 16403\/3655 Isotype: IgG2a, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2756","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2756","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2756"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2756"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2756"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2756"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}