{"id":2757,"date":"2020-11-30T12:09:48","date_gmt":"2020-11-30T12:09:48","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2757"},"modified":"2020-11-30T12:09:48","modified_gmt":"2020-11-30T12:09:48","slug":"anti-mouse-cd54-icam-1-antibody-clone-yn1-1-7-4-rat-monoclonal-igg2b-antibody-against-mouse-cd54","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-cd54-icam-1-antibody-clone-yn1-1-7-4-rat-monoclonal-igg2b-antibody-against-mouse-cd54\/","title":{"rendered":"Anti-Mouse CD54 (ICAM-1) Antibody, Clone YN1\/1.7.4 Rat monoclonal IgG2b antibody against mouse CD54"},"content":{"rendered":"

\"\"<\/p>\n

 <\/p>\n

\n
\n

Overview<\/h3>\n
\n
\n
The YN1\/1.7.4 antibody reacts with CD54, a 90 – 110 kDa type I transmembrane glycoprotein that is a member of the immunoglobulin (Ig) superfamily. CD54 consists of five Ig-like C2 type domains and has two isoforms generated from alternative splicing. As an important intercellular adhesion molecule, CD54 is involved in inflammatory reactions, antigen-specific immune responses, lymphocyte trafficking, and T cell signal transduction events. CD54 mediates important cell-cell interactions and adhesion reactions by binding to its major ligands, LFA-1 (CD11a\/CD18) and Mac-1 (CD11b\/CD18). CD54 may also act as a receptor for rhinoviruses and some coxsackieviruses. CD54 is expressed on lymphocytes, monocytes, macrophages, dendritic cells, endothelial cells, and high endothelial venules. Expression of CD54 is upregulated on activated lymphocytes and also, following stimulation with inflammatory mediators such as cytokines, LPS, and IFN-\u03b3.<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
<\/div>\n
\n
\n
\n
\n
\n
Subtype: Primary Antibodies<\/div>\n<\/div>\n
\n
Target Antigen: CD54 (ICAM-1)<\/div>\n<\/div>\n
\n
Alternative Names: BB2, Cell surface glycoprotein P3.58, Human rhinovirus receptor, Intercellular adhesion molecule 1, Ly-47, MALA2, MyD10<\/div>\n<\/div>\n
\n
Reactive Species: Mouse<\/div>\n<\/div>\n
\n
Conjugation: Unconjugated<\/div>\n<\/div>\n
\n
Host Species: Rat<\/div>\n<\/div>\n
\n
Cell Type: Endothelial Cells<\/div>\n<\/div>\n
\n
Application: Cell Isolation; Flow Cytometry; Immunoblotting; Immunoprecipitation<\/div>\n<\/div>\n
\n
Area of Interest: Immunology<\/div>\n<\/div>\n
\n
Clone: YN1\/1.7.4<\/div>\n<\/div>\n
\n
Gene ID: 15894<\/div>\n<\/div>\n
\n
Isotype: IgG2b, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The YN1\/1.7.4 antibody reacts with CD54, a 90 – 110 kDa type I transmembrane glycoprotein that is a member of the immunoglobulin (Ig) superfamily. CD54 consists of five Ig-like C2 type domains and has two isoforms generated from alternative splicing. As an important intercellular adhesion molecule, CD54 is involved in inflammatory reactions, antigen-specific immune responses, lymphocyte trafficking, and T cell signal transduction events. CD54 mediates important cell-cell interactions and adhesion reactions by binding to its major ligands, LFA-1 (CD11a\/CD18) and Mac-1 (CD11b\/CD18). CD54 may also act as a receptor for rhinoviruses and some coxsackieviruses. CD54 is expressed on lymphocytes, monocytes, macrophages, dendritic cells, endothelial cells, and high endothelial venules. Expression of CD54 is upregulated on activated lymphocytes and also, following stimulation with inflammatory mediators such as cytokines, LPS, and IFN-\u03b3. Subtype: Primary Antibodies Target Antigen: CD54 (ICAM-1) Alternative Names: BB2, Cell surface glycoprotein P3.58, Human rhinovirus receptor, Intercellular adhesion molecule 1, Ly-47, MALA2, MyD10 Reactive Species: Mouse Conjugation: Unconjugated Host Species: Rat Cell Type: Endothelial Cells Application: Cell Isolation; Flow Cytometry; Immunoblotting; Immunoprecipitation Area of Interest: Immunology Clone: YN1\/1.7.4 Gene ID: 15894 Isotype: IgG2b, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2757","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2757"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2757"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2757"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}