{"id":2771,"date":"2020-11-30T14:53:22","date_gmt":"2020-11-30T14:53:22","guid":{"rendered":"https:\/\/mira-lab.com\/?post_type=product&p=2771"},"modified":"2020-11-30T14:53:22","modified_gmt":"2020-11-30T14:53:22","slug":"anti-mouse-tcr-gamma-delta-antibody-clone-gl3-hamster-armenian-monoclonal-igg2-antibody-against-mouse-t-cell-receptor-gamma-delta","status":"publish","type":"product","link":"https:\/\/mira-lab.com\/new\/product\/anti-mouse-tcr-gamma-delta-antibody-clone-gl3-hamster-armenian-monoclonal-igg2-antibody-against-mouse-t-cell-receptor-gamma-delta\/","title":{"rendered":"Anti-Mouse TCR Gamma\/Delta Antibody, Clone GL3 Hamster (Armenian) monoclonal IgG2 antibody against mouse T Cell receptor gamma\/delta"},"content":{"rendered":"

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Overview<\/h3>\n
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The GL3 antibody reacts with the \u03b4 chain of the murine T cell receptor \u03b3\/\u03b4 (TCR\u03b3\/\u03b4 or TCR gamma\/delta), a subtype of the TCR involved in the recognition of both peptide and lipid antigens. TCR\u03b3\/\u03b4 comprises a heterodimer (~ 80 kDa in humans) of disulfide-linked \u03b3 and \u03b4 subunits that associates with CD3 on the cell surface. It is a member of the immunoglobulin superfamily. TCR\u03b3\/\u03b4 is expressed on a subpopulation of T cells in the circulation but may be found on up to 50% of the T cells in epithelial cell-rich tissues. These cells have roles in oral and tumor-associated tolerance as well as autoimmune disease and have been described as a link between the adaptive and innate immune responses. Once activated, they secrete effector cytokines in a subtype- and context-specific manner. Most \u03b3\/\u03b4 T cells are CD4-\/CD8-, though some express CD8. The GL3 antibody recognizes an epitope in the constant region of the \u03b4 chain and can reportedly activate TCR\u03b3\/\u03b4+ cells.<\/div>\n<\/div>\n<\/div>\n
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Subtype: Primary Antibodies<\/div>\n<\/div>\n
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Target Antigen: T Cell Receptor Gamma\/Delta<\/div>\n<\/div>\n
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Alternative Names: Gamma\/Delta TCR , gdTCR, TCRgd, TCR \u03b3\/\u03b4, T cell receptor delta chain, T cell receptor gamma chain, T cell receptor \u03b3\/\u03b4, T3D, T3G<\/div>\n<\/div>\n
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Reactive Species: Mouse<\/div>\n<\/div>\n
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Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; Unconjugated<\/div>\n<\/div>\n
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Host Species: Hamster<\/div>\n<\/div>\n
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Cell Type: T Cells; T Cells, Other Subsets<\/div>\n<\/div>\n
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Application: Cell Isolation; Functional Assay; Flow Cytometry; Depletion; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Neutralization and Blocking<\/div>\n<\/div>\n
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Area of Interest: Immunology<\/div>\n<\/div>\n
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Clone: GL3<\/div>\n<\/div>\n
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Gene ID: 110066\/110067<\/div>\n<\/div>\n
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Isotype: IgG2, kappa<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  Overview The GL3 antibody reacts with the \u03b4 chain of the murine T cell receptor \u03b3\/\u03b4 (TCR\u03b3\/\u03b4 or TCR gamma\/delta), a subtype of the TCR involved in the recognition of both peptide and lipid antigens. TCR\u03b3\/\u03b4 comprises a heterodimer (~ 80 kDa in humans) of disulfide-linked \u03b3 and \u03b4 subunits that associates with CD3 on the cell surface. It is a member of the immunoglobulin superfamily. TCR\u03b3\/\u03b4 is expressed on a subpopulation of T cells in the circulation but may be found on up to 50% of the T cells in epithelial cell-rich tissues. These cells have roles in oral and tumor-associated tolerance as well as autoimmune disease and have been described as a link between the adaptive and innate immune responses. Once activated, they secrete effector cytokines in a subtype- and context-specific manner. Most \u03b3\/\u03b4 T cells are CD4-\/CD8-, though some express CD8. The GL3 antibody recognizes an epitope in the constant region of the \u03b4 chain and can reportedly activate TCR\u03b3\/\u03b4+ cells. Subtype: Primary Antibodies Target Antigen: T Cell Receptor Gamma\/Delta Alternative Names: Gamma\/Delta TCR , gdTCR, TCRgd, TCR \u03b3\/\u03b4, T cell receptor delta chain, T cell receptor gamma chain, T cell receptor \u03b3\/\u03b4, T3D, T3G Reactive Species: Mouse Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; Unconjugated Host Species: Hamster Cell Type: T Cells; T Cells, Other Subsets Application: Cell Isolation; Functional Assay; Flow Cytometry; Depletion; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Neutralization and Blocking Area of Interest: Immunology Clone: GL3 Gene ID: 110066\/110067 Isotype: IgG2, kappa<\/p>\n","protected":false},"featured_media":2577,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[138],"product_tag":[],"class_list":["post-2771","product","type-product","status-publish","has-post-thumbnail","product_cat-antibodies","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/2771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/2577"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=2771"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=2771"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=2771"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=2771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}