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Plasmin is active enzyme, it takes part as in primary as in second fibrinolysis, it circulates in plasma in big quantities as its inactive precursor
\nplasminogen. Plasminogen can activate to plasmin by different ways, the most important one is activation by natural tissue activator, which synthesizes and releases by endothelial
\ncells. Plasminogen can be activated by external activators, such as streptokinase of hemolytic streptococcus and urokinase, natural nephritic
\nactivator. Plasminogen consumption is observed as in primary as in secondary fibrinolysis. Secondary fibrinolysis, which is connected with disseminated
\nintravascular clotting, is one of the most important reasons of plasminogen consumption. From other side, primary fibrinolysis, including only
\nfibrinolytic mechanism, causes rapid consumption of circulatory enzyme.
\nPrinciple. Method of the detection of plasminogen activity in the sample of blood plasma is based on its ability to form complex with streptokinase,
\nwhich hydrolyzes peptide chromogen substrate. Quantity of released pNA is directly proportional to
\nplasminogen activity in plasma sample. Process has following scheme:
\nPlasminogen + streptokinase (surplus) ==> complex
\nComplex + peptide \u2013 pNA ==> peptide + pNA<\/p>\n
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REACHROM-PLASMINOGEN<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":" Plasmin is active enzyme, it takes part as in primary as in second fibrinolysis, it circulates in plasma in big quantities as its inactive precursor plasminogen. Plasminogen can activate to plasmin by different ways, the most important one is activation by natural tissue activator, which synthesizes and releases by endothelial cells. Plasminogen can be activated by external activators, such as streptokinase of hemolytic streptococcus and urokinase, natural nephritic activator. Plasminogen consumption is observed as in primary as in secondary fibrinolysis. Secondary fibrinolysis, which is connected with disseminated intravascular clotting, is one of the most important reasons of plasminogen consumption. From other side, primary fibrinolysis, including only fibrinolytic mechanism, causes rapid consumption of circulatory enzyme. Principle. Method of the detection of plasminogen activity in the sample of blood plasma is based on its ability to form complex with streptokinase, which hydrolyzes peptide chromogen substrate. Quantity of released pNA is directly proportional to plasminogen activity in plasma sample. Process has following scheme: Plasminogen + streptokinase (surplus) ==> complex Complex + peptide \u2013 pNA ==> peptide + pNA REACHROM-PLASMINOGEN The kit of reagents for the determination plasminogen activity by photometric method. Cat. # FA-2 for 40 assays. Reagents: – concentrated buffer (5 mL) \u2013 1 vial; – streptokinase (1 mL), lyophilized \u2013 2 vials; – calibration plasma (1 mL), lyophilized \u2013 1 vial; – chromogenic substrate (2 mL), lyophilized \u2013 2 vials <\/p>\n","protected":false},"featured_media":4424,"template":"","meta":{"nf_dc_page":""},"product_brand":[],"product_cat":[206],"product_tag":[],"class_list":["post-4423","product","type-product","status-publish","has-post-thumbnail","product_cat-renam","cms-has-post-thumbnail","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product\/4423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media\/4424"}],"wp:attachment":[{"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/media?parent=4423"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_brand?post=4423"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_cat?post=4423"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mira-lab.com\/new\/wp-json\/wp\/v2\/product_tag?post=4423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nThe kit of reagents for the determination plasminogen activity by<\/strong>
\nphotometric method.<\/strong>
\nCat. # FA-2 for 40 assays.
\nReagents:
\n– concentrated buffer (5 mL) \u2013 1 vial;
\n– streptokinase (1 mL), lyophilized \u2013 2 vials;
\n– calibration plasma (1 mL), lyophilized \u2013 1 vial;
\n– chromogenic substrate (2 mL), lyophilized \u2013 2 vials<\/p>\n