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Anti-Human CD235ab (Glycophorin A/B) Antibody, Clone HIR2 Mouse monoclonal IgG2b antibody against human CD235ab (glycophorin A/B)

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Overview

The HIR2 (GA-R2) antibody recognizes an epitope common to the N-terminal region of human CD235a (glycophorin A) and CD235b (glycophorin B), homologous type I sialoglycoproteins of the erythrocyte (red blood cell) membrane that bear the antigenic determinants for the MN and Ss blood groups. CD235ab is expressed on early- and late-stage erythroblasts, mature erythrocytes, and erythroid cell lines such as K562 and HEL, but not on other cell types. CD235a is abundantly expressed whereas CD235b is a relatively minor membrane component. The proteins are believed to provide a large mucin-like surface to erythrocytes that acts to minimize aggregation in the circulation. The HIR2 antibody binds with higher affinity to CD235a than CD235b, and agglutinates untreated erythrocytes.
Subtype: Primary Antibodies
Target Antigen: CD235ab (Glycophorin A/B)
Alternative Names: CD235a, CD235ab, CD235b, Glycophorin A, Glycophorin B, GPA, GPB, GYPA, GYPB, MN sialoglycoprotein, PAS-2, PAS-3, Sialoglycoprotein alpha, Sialoglycoprotein delta, SS-active sialoglycoprotein
Reactive Species: Human
Conjugation: APC; Biotin; FITC; PE; Unconjugated
Host Species: Mouse
Cell Type: Red Blood Cells
Application: Flow Cytometry; Immunofluorescence; Immunocytochemistry; Immunohistochemistry; Immunoprecipitation; CyTOF; Western Blotting
Area of Interest: Immunology
Clone: HIR2 (GA-R2)
Gene ID: 2993/2994
Isotype: IgG2b, kappa
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