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Anti-Human CD45RO Antibody, Clone UCHL1 Mouse monoclonal IgG2a antibody against human, chimpanzee, common marmoset CD45RO

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Overview

The UCHL1 antibody reacts with an extracellular epitope on CD45RO, which is the shortest isoform of CD45, a type I transmembrane glycoprotein and member of the protein tyrosine phosphatase family (receptor class 1/6 subfamily). Alternative splicing of exons 4, 5 and 6 that encode the extracellular RA, RB and RC polypeptides of CD45 gives rise to up to 8 isoforms with molecular masses of 180 – 240 kDa. Excision of all three exons generates the ~180 kDa CD45RO isoform, which is expressed on activated and memory (but not naïve) T cells, some B cell subsets, activated monocytes and macrophages, and granulocytes. CD45RO enhances both T cell receptor- and B cell receptor-mediated activation and is a known ligand for CD22 on B cells. The UCHL1 antibody has been used to identify T cell lymphomas and leukemia and is commonly used in combination with antibodies against CD45RA to discern memory and naïve T cells. The proportion of CD45RO+ (memory) T cells typically increases with age. The UCHL1 epitope is destroyed by treatment with neuraminidase or O-glycosidase.
Subtype: Primary Antibodies
Target Antigen: CD45RO
Alternative Names: B220, CD45, GP180, LCA, L-CA, LY5, Protein tyrosine phosphatase receptor type C, PTPRC, T200
Reactive Species: Common Marmoset; Chimpanzee; Human
Conjugation: Alexa Fluor 488; APC; Biotin; FITC; PE; PerCP-Cyanine5.5; Unconjugated
Host Species: Mouse
Cell Type: Leukocytes; T Cells; T Cells, CD4+; T Cells, CD8+
Application: Cell Isolation; Electron Microscopy; ELISA; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Western Blotting
Area of Interest: Immunology; Stem Cell Biology
Clone: UCHL1
Gene ID: 5788
Isotype: IgG2a, kappa
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