Haemostasis is brought about by the interplay between the blood cells, the blood platelets, vessel endothelium and a set of proteins of the blood plasma, the factors of coagulation system.
Coagulation factors are synthesized mainly in liver and circulate in blood plasma in inactive form of proenzymes. During damaging influence
proenzymes begin to activate each other in order to form fibrin clot for hemorrhage prevention.
The kit is intended for diagnostics of Hemophilia A and thrombophilia, observation for treatment results and for control testing of anti-hemophilic pharmaceuticals.
Principle. The base of the method is APTT test in diluted sample. Reduced coagulation factors activity is compensated by adding substrate
plasma in incubation medium, which doesn’t contain FVIII but contains full activity of other coagulation factors. So, activity of FVIII in tested
sample is the only unknown detecting speed of coagulation process.
Quantitative detection of factor VIII is made under calibration graph of dilutions of plasma-calibrator
with certified factor VIII activity.

FACTOR VIII-TEST
The kit of reagents for FVIII activity determination.
Cat. # FC-1 for 20 assays.
Reagents:
– calibration plasma “RENAM” (1 mL), lyophilized – 1 vial;
– substrate plasma (1 mL), activity of factor VIII less than 1%, lyophilized – 1 vial;
– erilid (cephalin analog) (1 mL), lyophilized – 1 vial;
– kaolin suspension in 0.9 % solution of sodium chloride (5 mL) – 1 vial;
– imidazole buffer concentrated (5 mL) – 1 vial;
– 0.025 M solution of calcium chloride (5 mL) – 1 vial

FACTOR IX-TEST
The kit of reagents for F IXb activity determination. Cat. # FC-2-for 20 assays.
The kit of reagents is intended for diagnostics of Hemophilia B and thrombophilia, observationfor treatment results and
for control testing of antihemophilic pharmaceuticals.

FACTOR VIII
DEFICIENT PLASMA Cat. # CM-6 (3 vials).

FACTOR XIII-TEST
The kit of reagents for fibrin-stabilizing factor activity determination. Cat. # FC-3 for 40 assays.
Reducing of FXIII level is observed among patients with
innate deficit and secondary syndrome at heavy liver injury, sepsis, radiation
sickness, after heavy operations. Clinical picture of FXIII deficit is shown by
heavy hemorrhagic syndrome, bleeding duration may be 12- 36 hours.

PATOPLASMA VIII
The control plasma with pathological value of F VIII.
Cat. # CM-8/9 (plasma with F VIII activity~20% – 3 vials,
plasma with F VIII activity~200% – 3 vials).

FACTOR II
DEFICIENT PLASMA Cat. # CM-11 (3 vials).

FACTOR XI
DEFICIENT PLASMA Cat. # CM-14 (3 vials).

FACTOR VII
DEFICIENT PLASMA Cat. # CM-12 (3 vials).

FACTOR XII
DEFICIENT PLASMA Cat. # CM-15 (3 vials).

FACTOR X
DEFICIENT PLASMA Cat. # CM-13 (3 vials).