Being able to monitor cell cultures over time, provides great insight in their dynamics and function. Live cell imaging microscopes open up novel and exciting avenues, to study cell health, viability, colony formation, migration and cellular responses to external factors.
To help researchers in life sciences to continue improving their understanding of cellular processes, CytoSMART Technologies has developed an automated bright-field lab microscope that visualizes complete culture vessels and operates from inside standard CO2-incubators. Perform kinetic assays by creating time-lapse videos that capture cellular behavior for days or even weeks at a time.
Continuous imaging provides real-time insight into cellular processes
Perform kinetic assays over the course of days or even weeks.
Time-lapse imaging allows you to pinpoint important events in the progression of the cell culture from experiment to experiment. Uncover attachment and detachment rates, evaluate events like cell death and compare growth rates. Data collection using video monitoring allows users to capture changes within samples and compare the rate of change between samples.
Complete overview of sample heterogeneity
Achieved by automated full plate scanning and image stitching
Manual handling and cell seeding can cause a variable density distribution within culture vessels. Randomly selecting several areas of interest or tile scanning is common practice to overcome that issue, however this is either time-consuming to set-up or to post-process. The CytoSMART Omni automatically scans complete well surface areas and instantly stitches these images to give users a complete overview of cell coverage.
High throughput assays or cell line production
Imaging of full plates, flasks, dishes and microfluidic devices
Cell based assays and subculturing all benefit from standardization. Choosing the right vessel and going through the process of understanding how cells behave in said vessel is vital for reproducibility. The CytoSMART Omni is highly flexible and is compatible to any transparent vessel that is lower than 55 mm. All vessels with a surface area smaller than 99*131 mm can be imaged in full.
- Label-free cellular assays
- Time-lapse videos
- Whole well surfaces
Perform analysis at desired culturing environment
The CytoSMART Omni is designed for your incubator
Live-cell imaging systems require environmental control during the experiment. To ensure the proper environmental conditions, users can place the compact CytoSMART Omni inside any standard cell culture incubator. The smooth curvatures of the CytoSMART Omni platform ensures minimal airflow disturbance. This ensures that your samples stay in their desired, homogeneous environment throughout the entire experiment.
Ensure sample stability while imaging
Produce bright-field images without moving your samples
Acquiring images can by highly disturbing to living cells. Environmental shock, like sudden changes in the atmosphere and mechanical disturbance can negatively influence cell viability. The CytoSMART Omni rapidly captures bright field images at cell-level detail without disturbing the cells. Users can set the desired imaging parameters using their own computer and the CytoSMART Omni will follow that scanning regime. At no point after placing the cells on the sample stage does the culture need to be moved. Automated time-lapse imaging eliminates the need for any manual interference. Imaging using such a stable system prevents unwanted disturbances and reduces imaging artifacts
Technical specifications
| Unit dimensions | 396 x 345 x 171 mm (L x W x H) |
|---|---|
| Weight | 9 kg |
| Optics | Bright-field with digital phase contrast |
| Magnification | 10x fixed objective |
| Light source | LED |
| Camera | 5 MP CMOS |
| Scan area | 99 * 131 mm |
| Exported formats | JPG, XLSX & MP4 |
| Well plate types | 6 – 96 well plates |
| Culture flask types | petri dishes, T25 – T225, triple flasks and HYPERFlasks |
| Other labware | Anything transparent and lower than 55 mm |
| Operating environment | 5-40 °C, 20-95% humidity |
| Support | Via email and live chat |
| Research use only. Not intended for diagnostic purposes |
