Overview
The N418 antibody reacts with CD11c (αX integrin), a 150 kDa type 1 transmembrane glycoprotein that associates non-covalently with CD18 (β2 integrin) to form a heterodimeric cell surface adhesion receptor. Through its interaction with ligands such as iC3b, fibrinogen, and CD54, the CD11c/CD18 receptor is involved in several immune response processes, including cell migration, stimulation of cytokine production by monocytes and macrophages, T cell proliferation, leukocyte recruitment, and phagocytosis. In mice, CD11c is expressed on dendritic cells, macrophages, monocytes, granulocytes, NK cells, and a subset of T cells.
This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse CD11c Positive Selection Kit II
Subtype: Primary Antibodies
Target Antigen: CD11c
Alternative Names: alphaX integrin, CR4, integrin alphaX chain, p150
Reactive Species: Mouse
Conjugation: Biotin; FITC; PE; Unconjugated
Host Species: Hamster
Cell Type: Dendritic Cells
Application: CyTOF; Flow Cytometry; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation
Area of Interest: Immunology
Clone: N418
Gene ID: 16411
Isotype: IgG
