Overview
The 1D3 antibody reacts with mouse CD19, an ~95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells. Expression is down-regulated but persists in terminally differentiated plasma cells. CD19 is also found on follicular dendritic cells. By associating with CD21 and CD81, CD19 functions as a co-receptor for the B cell receptor and is involved in B cell activation and differentiation. Activation of CD19 is accompanied by phosphorylation of the cytoplasmic domain, which promotes binding to kinases and the induction of intracellular signaling cascades. Mutations in CD19 can result in severe immunodeficiency syndromes. Clone 1D3 recognizes the same epitope as clone 6D5 in cross-competition assays.
Subtype: Primary Antibodies
Target Antigen: CD19
Alternative Names:
B4
Reactive Species:
Mouse
Conjugation:
APC; Biotin; FITC; PE; PerCP-Cyanine5.5; Unconjugated
Host Species:
Rat
Cell Type:
B Cells
Application:
Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation
Area of Interest:
Immunology
Clone:
1D3
Gene ID:
12478
Isotype:
IgG2a, kappa
