Overview
The DECMA-1 antibody recognizes E-cadherin, a calcium-dependent transmembrane glycoprotein involved in cell-cell adhesion, bacterial pathogenesis, and tumor invasion. The extracellular region of E-cadherin is composed of multiple cadherin repeats that contain calcium-binding motifs. The cytoplasmic domain of E-cadherin is reported to interact with a range of intracellular proteins including erbin, ezrin, caspase-3, caspase-8, β-catenin, presenilin 1, and casein kinase II. E-cadherin is expressed in most epithelial cells and in erythroid cells. The E-cadherin antibody is often used as a neutralizing antibody to inhibit E-cadherin-mediated cell-cell interactions.
Subtype: Primary Antibodies
Target Antigen: E-Cadherin (CD324)
Alternative Names: Arc 1, Cadherin-1, CAM 120/80, CDHE, CDH1, E-Cad/CTF3, Epithelial cadherin, epithelial calcium-dependent adhesion protein, LCAM, Liver cell adhesion molecule, UVO, Uvomorulin
Reactive Species: Human; Mouse; Pig; Dog
Conjugation: Unconjugated
Host Species: Rat
Cell Type: Airway Cells
Application: Flow Cytometry; Immunocytochemistry; Immunofluorescence; Immunoprecipitation; Western Blotting; Functional Assay
Area of Interest: Endothelial Cell Biology
Clone: DECMA-1
Gene ID: 999/12550
Isotype: IgG1, kappa
