Overview
SHIP2 is a 145 kDa SHIP-related protein expressed in both hematopoietic and nonhematopoietic cells. Like SH2-containing inositol phosphatase (SHIP), SHIP2 becomes tyrosine phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP2 also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse and human full-length 145 kDa SHIP2 protein.
Subtype: Primary Antibodies
Target Antigen: SHIP2
Alternative Names: Inositol polyphosphate phosphatase like 1, INPPL1, OPSMD
Reactive Species: Mouse; Human
Conjugation: Unconjugated
Host Species: Rabbit
Cell Type: Granulocytes and Subsets; Lymphocytes; Myeloid Cells
Application: Immunoblotting; Immunoprecipitation
Area of Interest: Immunology
Clone: Not applicable
Gene ID: 3636 (human), 16332 (mouse)
Isotype: Not applicable
