Overview
The 40 antibody clone reacts with OCT-3/4, also known as POU5F1, a transcription factor that is essential for the formation of the inner cell mass during mouse development and for the maintenance of undifferentiated mouse and human embryonic stem (ES) and induced pluripotent stem (iPS) cells. It is expressed at high levels in undifferentiated mouse and human ES and iPS cells and in embryonic germ cells (EGCs), and exhibits decreased expression during differentiation. It is commonly used as a marker for the assessment of undifferentiated ES and iPS cells, and EGCs from multiple species.
Subtype: Primary Antibodies
Target Antigen: OCT4 (OCT3)
Alternative Names: Oct3, OTF3, Oct4, OTF4, POU5F1
Reactive Species: Mouse; Human
Conjugation: Unconjugated
Host Species: Mouse
Cell Type: Pluripotent Stem Cells
Application: Flow Cytometry; Immunofluorescence; Western Blotting
Area of Interest: Stem Cell Biology
Clone: 40
Gene ID: 18999 (mouse), 5460 (human)
Isotype: IgG1, kappa
