Overview
Phospho-SHIP is a highly phosphorylated form of SHIP. SH2-containing inositol phosphatase (SHIP) is a 145 kDa hematopoietic-restricted protein that becomes tyrosine-phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse and human tyrosine-phosphorylated SHIP.
Subtype: Primary Antibodies
Target Antigen: PhosphoSHIP
Alternative Names: p150Ship; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; SHIP-1; SHIP1; SIP-145; s-SHIP
Reactive Species: Mouse; Human
Conjugation: Unconjugated
Host Species: Rabbit
Cell Type: Granulocytes and Subsets; Lymphocytes; Myeloid Cells
Application: Immunoblotting; Immunoprecipitation; Flow Cytometry; Immunofluorescence
Area of Interest: Immunology
Clone: Not applicable
Gene ID: 3635 (human), 16331 (mouse)
Isotype: Not applicable
