Overview
Ym1 is an ~45 kDa secreted protein synthesized by activated mouse peritoneal macrophages during the inflammatory response elicited by parasitic infections. Ym1 is a granule protein in neutrophils and has been purified from eosinophilic crystals that form in the bronchoalveolar lavage fluid of mev/mev and SHIP (SH2-containing inositol 5’ phosphatase) knockout mice. The eosinophilic crystals formed in mice are considered to be histologically identical to the Charcot-Leyden crystals found in humans. Ym1 is homologous to T lymphocyte-derived eosinophil chemotactic factor (ECF-L) but elicits only a weak chemotactic response in eosinophils. Ym1 binds to heparin, GlcN oligomers and heparan sulfate. It belongs to a protein family related to chitinases but does not possess chitinase activity.
Subtype: Primary Antibodies
Target Antigen: Ym1
Alternative Names: beta-N-acetylhexosaminidase Ym1, Chi3l3, chitinase-like protein 3, ECF-L, eosinophil chemotactic cytokine, eosinophil chemotactic factor-L, secreted protein Ym1
Reactive Species: Mouse
Conjugation: Unconjugated
Host Species: Rabbit
Cell Type: Other
Application: Immunoblotting; Flow Cytometry; Immunofluorescence; Immunohistochemistry
Area of Interest: Immunology
Clone: Not applicable
Gene ID: 12655
Isotype: IgG
